北海道医療大学

業績

2023年度

  1. An increasing trend of gastric cancer deaths and inadequate preventive measures in elderly adults.
    Matsushima R, Matsushima S, Kobayashi M, Fujimori K, Sakamoto N, Asaka M.
    Helicobacter 2023 Aug;28(4):e12988. doi: 10.1111/hel.
  2. Anticancer effects of fucoxanthin in a PDX model of advanced stage pancreatic cancer with alteration of several multifunctional molecules.
    Terasaki M, Sally Suzuki S, Tanaka T, Maeda H, Masaki Shibata M, Miyashita K, Kuramitsu Y, Hamada J, Tohru Ohta T, Yagishita S, Hamada A, Sakamoto Y, Hijioka S, Chigusa Morizane C, Takahashi M.
    Onco 2023, 3, 217–236.
    https://doi.org/10.3390/onco3040016
  3. The identification of tyrosine-nitrated human serum albumin in airborne particulate matter from Japan.
    Ogino N, Ogino K, Eitoku M, Suganuma N, Nagaoka K, Kuramitsu Y.
    Atmospheric Pollution Research Volume 12, Issue 5, 101050, May 2021.
  4. Systemic administration of lipopolysaccharide from Porphyromonas gingivalis decreases neprilysin expression in the mouse hippocampus.
    Morikawa T, Uehara O, Paudel D, Yoshida K, Harada F, Hiraki D, Sato J, Matsuoka H, Kuramitu Y, Michikawa M, Abiko Y.
    In Vivo 37(1):163-172, 2023. doi: 10.21873/invivo.13065. PMID: 36593043
  5. Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis.
    Paudel D, Uehara O, Giri S, Yoshida K, Morikawa T, Kitagawa T, Matsuoka H, Miura H, Toyofuku A, Kuramitsu Y, Ohta T, Kobayashi M, Abiko Y.
    Jpn Dent Sci Rev 58:365-375, 2022. doi: 10.1016/j.jdsr.2022.11.003. PMID: 36425317
  6. Downregulating effect of a standardized extract of cultured Lentinula edodes mycelia on cortactin in prostate cancer cells is depended on malignant potential.
    Yamashita S, Tanaka Y, Kitagawa T, Baron B, Tokuda K, Paudel D, Nakagawa K, Ohta T, Hamada J, Kobayashi M, Nagayasu H, Kuramitsu Y.
    Anticancer Res 43(3):1159-1166, 2023. doi: 10.21873/anticanres.16261.
  7. A standardized extract of cultured Lentinula Edodes Mycelia up-regulates COX-2 in inflammation-related malignant progressive fibrosarcoma cell clone QRsP-11.
    Kitagawa T, Islam S, Baron B, Tokuda K, Paudel D, Ohta T, Nakagawa K, Kobayashi M, Okada F, Kuramitsu Y.
    Anticancer Res 43(3):1239-1244, 2023. doi: 10.21873/anticanres.16270.
  8. TPM1 is a novel biomarker for oral squamous cell carcinoma.
    Takenawa T, Ferdous T, Kawasaki K, Kuramitsu Y, Mishima K.
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology (in press)
  9. Yes-associated protein regulates cortical actin architecture and dynamics through intracellular translocation of Rho GTPase-activating protein 18.
    Zhang Y, Kitagawa T, Furutani-Seiki M, Yoshimura SH.
    FASEB J 2023 Sep;37(9):e23161. doi: 10.1096/fj.202201992R. PMID: 37638562
  10. Repeated exposure to kairomone-containing coffee odor improves abnormal olfactory behaviors in heterozygous oxytocin receptor knock-in mice.
    Osada K, Kujirai R, Hosono A, Tsuda M, Ohata M, Ohta T, Nishimori K.
    Front Behav Neurosci 2023 Feb 1;16:983421. doi: 10.3389/fnbeh.2022.983421. PMID: 36817409

2022年度

  1. Suzuki R, Saitou N, Matsuari O, Shiota S, Matsumoto T, Akada J, Kinjo N, Kinjo F, Teruya K, Shimoji M, Shiroma A, Kato M, Satou K, Hirano T, Asaka M, Kryukov K, Moodley Y, Yamaoka Y. Helicobacter pylori genomes reveal Paleolithic human migration to the east end of Asia.
    iScience 2022. 30;25(7):104477. doi: 10.1016/j.isci.2022.104477
  2. Kowada A, Asaka M. Economic and health impacts of Helicobacter pylori eradication strategy for the treatment of peptic ulcer disease: A cost-effectiveness analysis.
    Helicobacter 2022 Jun;27(3):e12886. doi: 10.1111/hel.
  3. AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing’s sarcoma cells.
    Kitagawa T, Kobayashi D, Baron B, Okita H, Miyamoto T, Takai R, Paudel D, Ohta T, Asaoka Y, Tokunaga M, Nakagawa K, Furutani-Seiki M, Araki N, Kuramitsu Y, Kobayashi M.
    PROS ONE (in press), 2022
  4. Proteomic and microbiota analyses of the oral cavity during psychological stress.
    Paudel D, Kuramitsu Y, Uehara O, Morikawa T, Yoshida K, Giri S, Islam ST, Kitagawa T, Kondo T, Sasaki K, Matsuoka H, Miura H, Abiko Y.
    PROS ONE 17(5):e0268155. doi: 10.1371/journal.pone.0268155, 2022
  5. Requirement of CLIC4 Expression in Human Colorectal Cancer Cells for Sensitivity to Growth Inhibition by Fucoxanthinol.
    Yokoyama R, Kushibiki A, Yamada S, Kubota A, Kojima H, Ohta T, Hamada J, Maeda H, Mutoh M, Terasaki M.
    Cancer Genomics Proteomics. 2022 Jul-Aug;19(4):428-444. doi: 10.21873/cgp.20330.
    PMID: 35732323
  6. A Biscuit Containing Fucoxanthin Prevents Colorectal Carcinogenesis in Mice.
    Terasaki M, Murase W, Kamakura Y, Kawakami S, Kubota A, Kojima H, Ohta T, Tanaka T, Maeda H, Miyashita K, Mutoh M.
    Nutr Cancer. 2022;74(10):3651-3661. doi: 10.1080/01635581.2022.2086703. Epub 2022 Jun 13.
    PMID: 35695489
  7. Induction of periodontal ligament-like cells by co-culture of dental pulp cells, dedifferentiated cells generated from Epithelial cell Rests of Malassez, and umbilical vein endothelial cells.
    Onishi A, Yoshida K, Morikawa T, Paudel D, Takahashi S, Khurelchuluun A, Ariwansa D, Harada F, Uehara O, Kurashige Y, Abiko Y.
    J Endod. 2022 Sep 3:S0099-2399(22)00573-8. doi: 10.1016/j.joen.2022.08.006. Online ahead of print. PMID: 36067833
  8. Gut flora alterations due to lipopolysaccharide derived from Porphyromonas gingivalis.
    Sugiyama N, Uehara O, Morikawa T, Paudel D, Ebata K, Hiraki D, Harada F, Yoshida K, Kato S, Nagasawa T, Miura H, Abiko Y, Furuichi Y.
    Odontology. 2022 Oct;110(4):673-681. doi: 10.1007/s10266-022-00703-x. Epub 2022 Mar 25. PMID: 35333990
  9. Alterations in the oral microbiome of individuals with a healthy oral environment following COVID-19 vaccination.
    Uehara O, Abiko Y, Nagasawa T, Morikawa T, Hiraki D, Harada F, Kawano Y, Toraya S, Matsuoka H, Paudel D, Shimizu S, Yoshida K, Asaka M, Furuichi Y, Miura H.
    BMC Oral Health. 2022 Mar 3;22(1):50. doi: 10.1186/s12903-022-02093-6.
    PMID: 35241064
  10. Analysis of the cells isolated from epithelial cell rests of Malassez through single-cell limiting dilution.
    Islam ST, Kurashige Y, Minowa E, Yoshida K, Paudel D, Uehara O, Okada Y, Bolortsetseg D, Sakakibara S, Abiko Y, Saitoh M.
    Sci Rep. 2022 Jan 10;12(1):382. doi: 10.1038/s41598-021-04091-0.
    PMID: 35013397
  11. A Population-Based Helicobacter pylori Eradication Strategy Is More Cost-Effective than Endoscopic Screening. Kowada A. Digestive Diseases and Sciences.
    PDF
  12. Systemic administration of lipopolysaccharide from Porphyromonas gingivalis decreases neprilysin expression in the mouse hippocampus.
    Morikawa T, Uehara O, Paudel D, Yoshida K, Harada F, Hiraki D, Sato J, Matsuoka H, Kuramitu Y, Michikawa M, Abiko Y.
    In Vivo (in press)
  13. Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis.
    Paudel D, Uehara O, Giri S, Yoshida K, Morikawa T, Kitagawa T, Matsuoka H, Miura H, Toyofuku A, Kuramitsu Y, Ohta T, Kobayashi M, Abiko Y.
    Jpn Dent Sci Rev 58:365-375, 2022. doi: 10.1016/j.jdsr.2022.11.003. PMID: 36425317
  14. Downregulating effect of a standardized extract of cultured Lentinula edodes mycelia on cortactin in prostate cancer cells is depended on malignant potential.
    Yamashita S, Tanaka Y, Kitagawa T, Baron B, Tokuda K, Paudel D, Nakagawa K, Ohta T, Hamada J, Kobayashi M, Nagayasu H, Kuramitsu Y.
    Anticancer Res (in press)
  15. A standardized extract of cultured Lentinula Edodes Mycelia up-regulates COX-2 in inflammation-related malignant progressive fibrosarcoma cell clone QRsP-11.
    Kitagawa T, Islam S, Baron B, Tokuda K, Paudel D, Ohta T, Nakagawa K, Kobayashi M, Okada F, Kuramitsu Y.
    Anticancer Res (in press)
  16. TPM1 is a novel biomarker for oral squamous cell carcinoma.
    Takenawa T, Ferdous T, Kawasaki K, Kuramitsu Y, Mishima K.
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology (in press)

2021年度

  1. Kowada A & Asaka M. Economic and health impacts of introducing Helicobacter pylori eradication strategy into national gastric cancer policy in Japan: A cost-effectiveness analysis.
    Helicobacter 2021 e12837.doi: 10.1111/hel.
  2. Metagenomic analyses of oral and vaginal microbiome in ovariectomized rats.
    Paudel D, Uehara O, Morikawa T, Yoshida K, Giri S, Kitagawa T, Nakao Y, Tsuchida J, Iijima M, Miura H, Kuramitsu Y, Abiko Y.
    Dent J Health Sci Univ Hokkaido 40(2):33-41, 2021.
  3. Antibody response to BNT162b2 mRNA vaccine in young and old health care workers and residents in long-term care facilities
    Kitagawa T, Kuramitsu Y, Nakagawa K, Ohta T, Akino K, Asaka M, Kobayashi M.
    Geriatrics & Gerontology International 22(2):179-181.
    2022 Jan 10. doi: 10.1111/ggi.14342. Online ahead of print.
    PMID: 35014140
  4. The expression level of vinculin in pancreatic cancer tissues significantly correlates with patient prognosis
    Islam S, Kitagawa T, Azuma T, Kuramitsu Y.
    Anticancer Research 41(10): 4979-4984. doi: 10.21873/anticanres.15311.
  5. Nine cases of SARS-CoV-2-PCR-positive samples showed no increase of antibodies against SARS-CoV-2.
    Kitagawa T, Kobayashi M, Ohta T, Tsukamoto Y, Terasaki M, Takai R, Ishizumi R, Uehara O, Nakagawa K, Akino K, Asaka M, Kuramitsu Y.
    In Vivo 35(5):2947-2949, 2021. doi: 10.21873/invivo.12587. PMID: 34410992
  6. High expression of PEA15 is associated with patient survival in malignant pleural mesothelioma
    Islam S, Kitagawa T, Kuramitsu Y.
    Cancer Diagnosis & Prognosis 1(4): 371-377, 2021. doi: 10.21873/cdp.10049
  7. An in vitro senescence model of gingival epithelial cell induced by hydrogen peroxide treatment.
    Giri S, Takada A, Paudel D, Yoshida K, Furukawa M, Kuramitsu Y, Matsushita K, Abiko Y, Furuichi Y
    Odontology 110(1):44-53. 2021. doi: 10.1007/s10266-021-00630-3. PMID: 34143349
  8. A standardized extract of cultured Lentinula edodes mycelia downregulates cortactin in gemcitabine-resistant pancreatic cancer cells
    Islam S, Kitagawa T, Baron B, Kuhara K, Nagayasu H, Kobayashi M, Chiba I, Kuramitsu Y
    Oncology Letters 22(3):654, 2021. doi: 10.3892/ol.2021.12915. PMID: 34386076
  9. ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis.
    Islam S, Kitagawa T, Baron B, Abiko Y, Chiba I, Kuramitsu Y.
    Scientific Reports 18;11(1):10563. 2021.
    doi: 10.1038/s41598-021-90077-x. PMID: 34007003
  10. Letter to the Editor: Prognostic significance of cofilin isoforms in patients with pancreatic ductal adenocarcinoma.
    Islam S, Kitagawa T, Kuramitsu Y.
    Pathology and Oncology Research 27:1609821, 2021.
    doi: 10.3389/pore.2021.1609821. PMID: 34257623
  11. Proteomic Analysis for Hepatocellular Carcinoma Tissues with Enapsulation Showed Up-regulation of Leucine Aminopeptidase 3 and Phosphoenolpyruvate Carboxykinase 2.
    Kuhara K, Kitagawa T, Baron B, Tokuda K, Sakamoto K, Nagano H, Nakamura K, Kobayashi M, Nagayasu H, Kuramitsu Y.
    Cancer Genomics & Proteomics18: 307-316, 2021.
    PMID: 33893083 Doi: 10.21873/cgp.20261
  12. Fucoxanthin Prevents Pancreatic Tumorigenesis in C57BL/6J Mice That Received Allogenic and Orthotopic Transplants of Cancer Cells.
    Murase W, Kamakura Y, Kawakami S, Yasuda A, Wagatsuma M, Kubota A, Kojima H, Ohta T, Takahashi M, Mutoh M, Tanaka T, Maeda H, Miyashita K, Terasaki M.
    Int J Mol Sci. 2021 Dec 19;22(24):13620. doi: 10.3390/ijms222413620.
    PMID: 34948416
  13. Suppression of C-C chemokine receptor 1 is a key regulation for colon cancer chemoprevention in AOM/DSS mice by fucoxanthin.
    Terasaki M, Ono S, Hashimoto S, Kubota A, Kojima H, Ohta T, Tanaka T, Maeda H, Miyashita K, Mutoh M.
    J Nutr Biochem. 2022 Jan;99:108871. doi: 10.1016/j.jnutbio.2021.108871. Epub 2021 Sep 24. PMID: 34571188
  14. Effects of CLIC4 on Fucoxanthinol-Induced Apoptosis in Human Colorectal Cancer Cells.
    Yokoyama R, Kojima H, Takai R, Ohta T, Maeda H, Miyashita K, Mutoh M, Terasaki M.
    Nutr Cancer. 2021;73(5):889-898. doi: 10.1080/01635581.2020.1779760. Epub 2020 Jun 17. PMID: 33703973
  15. A Fucoxanthinol Induces Apoptosis in a Pancreatic Intraepithelial Neoplasia Cell.
    Terasaki M, Inoue T, Murase W, Kubota A, Kojima H, Kojoma M, Ohta T, Maeda H, Miyashita K, Mutoh M, Takahashi M.
    Cancer Genomics Proteomics. 2021 Mar-Apr;18(2):133-146. doi: 10.21873/cgp.20248.
    PMID: 33608310
  16. A marine carotenoid of fucoxanthinol accelerates the growth of human pancreatic cancer PANC-1 cells.
    Terasaki M, Takahashi S, Nishimura R, Kubota A, Kojima H, Ohta T, Hamada J, Kuramitsu Y, Maeda H, Miyashita K, Takahashi M, Mutoh M.
    Nutrition and Cancer :1-16. 2021. PMID: 33590779 DOI: 10.1080/01635581.2020.1863994
  17. Psychological Backgrounds of Medically Compromised Patients and Its Implication in Dentistry: A Narrative Review.
    Abiko Y, Paudel D, Matsuoka H, Moriya M, Toyofuku A.
    Int J Environ Res Public Health. 2021 Aug 20;18(16):8792. doi: 10.3390/ijerph18168792. PMID: 34444548
  18. Bee Pollen Diet Alters the Bacterial Flora and Antimicrobial Peptides in the Oral Cavities of Mice.
    Khurelchuluun A, Uehara O, Paudel D, Morikawa T, Kawano Y, Sakata M, Shibata H, Yoshida K, Sato J, Miura H, Nagayasu H, Abiko Y.
    Foods. 2021 Jun 4;10(6):1282. doi: 10.3390/foods10061282. PMID: 34199731
  19. Direct reprogramming of epithelial cell rests of malassez into mesenchymal-like cells by epigenetic agents.
    Yoshida K, Uehara O, Kurashige Y, Paudel D, Onishi A, Neopane P, Hiraki D, Morikawa T, Harada F, Takai R, Sato J, Saitoh M, Abiko Y.
    Sci Rep. 2021 Jan 20;11(1):1852. doi: 10.1038/s41598-020-79426-4. PMID: 33473142
  20. Aberrant expression of DUSP4 is a specific phenomenon in betel quid-related oral cancer.
    Adhikari BR, Yoshida K, Paudel D, Morikawa T, Uehara O, Sato J, Muthumala M, Amaratunga P, Arakawa T, Chiba I, Abiko Y.
    Med Mol Morphol. 2021 Jun;54(2):79-86. doi: 10.1007/s00795-020-00265-3. Epub 2020 Sep 20. PMID: 32951127

2020年度

  1. Tsuda M, Kato M, Ono S, Matsuda K, Miyamoto S, Abiko S, Ono M, Mizushima T, Yamamoto K, Nakagawa M, Mabe K, Nakagawa S, Kudo T, Nishikawa K, Shimizu Y, Asaka M, Sakamoto N. Changes of Dyspeptic Symptom after Successful Eradication in Helicobacter pylori-Associated Dyspepsia.
    Digestion 2020;101(2):165-173
  2. DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing—a possible predictive biomarker for malignant transformation. S Islam, O Uehara, H Matsuoka, et al. Clinical Epigenetics (2020) 12:12
  3. P. gingivalis Lipopolysaccharide Stimulates the Upregulated Expression of the Pancreatic Cancer-Related Genes Regenerating Islet-Derived 3 A/G in Mouse Pancreas. D Hiraki, O Uehara, Y Kuramitsu, et al. Int. J. Mol. Sci. 2020, 21, 7351
  4. Alteration of oral flora in betel quid chewers in Sri Lanka. O Uehara, D Hiraki, Y Kuramitsu, et al. Journal of Microbiology, Immunology and Infection.
    https://doi.org/10.1016/j.jmii.2020.06.009
  5. A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells. M Terasaki, S Takahashi, R Nishimura, et al. Nutrition and Cancer
    https://www.tandfonline.com/loi/hnuc20
  6. Gastric cancer deaths by age group in Japan: Outlook on preventive measures for elderly adults. M Asaka, M Kobayashi, T Kudo, et al. Cancer Science. 2020;00:1–9.
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