2023.01.06Research-No.27(出典)Kasai Y, Sato K*, Utsumi S, Ichikawa S*. Improvement of SN Ar Reaction Rate by an Electron-withdrawing Group in the Cross-linking of DNA Cytosine-5 Methyltransferase by a Covalent Oligodeoxyribonucleotide Inhibitor. ChemBioChem 2018, 19, 1866-1872. Sato K*, Kunitomo Y, Kasai Y, Utsumi S, Suetake I, Tajima S, Ichikawa S, Matsuda A. Mechanism-based Inhibitor of DNA Cytosine-5 Methyltransferase (DNMT) via a SN Ar Reaction with an Oligodeoxyribonucleotide Containing 2-Amino-4-Halopyridine-C-Nucleoside (d XP). ChemBioChem 2018, 19, 865-872.
タンパク質と結合する核酸医薬品の創製
薬学部
佐藤 浩輔准教授
