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Huff J W, Perlzweig W A |
A product of oxidative metabolism of pyridoxine, 2-methyl-3-hydroxy-4-carboxy-5-hydroxy-methylpyridine(4-pyridoxic acid) I. Isolation from urine, structure, and synthesis. |
J Biol Chem. |
(1944) 155: 345-355. |
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Ott WH |
Antipyridoxine activity of methoxypyridoxine in the chick. |
Proc Soc Exp Biol Med. |
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Schwartz R, Kjeldgaard N O |
The enzymic oxidation of pyridoxal by liver aldehyde oxidase. |
Biochem. J. |
(1951) 48: 333-337. |
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Takano, T., Kobayashi, M., Wada, I. |
Study on Gin-nan food poisoning in experimental animals (in Japanese). |
Jui Chikusan Shinpo |
(1953)109: 353-357. |
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Umbreit WW |
Vitamin B6 Antagonists. |
Am J Clin Nutrition |
(1955) 3:291-297. |
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Gammon GD, Gummit R |
Observations on the mechanism of seizures induced by a pyridoxine antagonist, methoxypyridoxine. |
Trans Am Neurol Assoc |
(1957) 82: 57-59. |
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Kobayashi, M. |
Study on the toxic substance in Ginkgo seeds. (in Japanese). |
Nagano-ken Eisei Kenkyusho Chosa Kenkyu Hokoku |
(1959) 16:1-12 |
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Suzu M |
An examination of plums and ginkgo-nuts for cyanophoric glycoside. (in Japanese) |
Fukuoka Igaku Zasshi |
(1959) 50: 5394-5398. |
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Kamrin R P, Kamrin A A |
The effects of pyridoxine antagonists and other convulsive agents on amino acid conceutrations of the mouse brain. |
J. Neurochemistry |
(1961) 6: 219-225. |
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Kraft Von H G, Fiebig L, Hotovy R |
Pharmacology of vitamin B6 and its derivatives.(in German) |
Arzneimitel-Forsh |
(1961) 10: 922-929. |
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Kopeloff LM, Chusid JG |
Methoxypyridoxine convulsions in epileptic and non-epileptic mice. Protective action of pyridoxine. |
Proc Soc Exp Biol Med. |
(1963) 114: 496-500. |
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Julou L, Pasquet J, Ducrot R |
The antidotic effect of pyridoxineon one of the intermediary products of its manufacture which has a strong toxicity. |
Proc of European Society for the Study of Drug Toxicity |
(1964) 4: 179-189. |
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Elliot K A C |
g-Aminobutyric acid and other inhibitory substitutes. |
Brit Med Bull. |
(1965)21: 70-75. |
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Provocation of cerebral seizures by derangement of the natural balance between glutamic acid and g-aminobutyric acid. |
J Neurochem |
(1966)13: 59-64. |
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Steiner F A, Ruf K |
Interaction of L-glutamic acid gamma-amino butyric acid and pyridoxal-5'-phosphate at the neuronal level. |
Schweizer Archiv of Neurologie, Arch Neurol Neurochirurgie und Psychiatrie |
(1967)100: 310-320. |
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Klosterman, H. J., Lamoureux, G. L., and Parsons, J. L. |
Isolation, characterization, and synthesis of linatine. A vitamin B6 antagonist from flaxseed (Linum usitatissimum). |
Biochemistry |
(1967)6: 170-177. |
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Yoshida T, Tada K, Arakawa T |
Vitamin B6-dependency of glutamic acid decarboxylase in the kidney from a patient with vitamin B6 dependent convulsion.(In Japanese) |
Tohoku J Exp Med. |
(1971)104: 195-198. |
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Cherayil G D, Cyrus A E Jr |
Effect of 4-methoxymethyl-pyridoxine on gangliosides, cholesterol and fatty acids in mouse brain. |
J. Neurochem. |
(1972)19 :1215-1219. |
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Somogyi, J.C. |
Antivitamins. |
In Committee on Food Protection, Food and Nutrition Board, National Research Council, (ed.), Toxicants Occurring Naturally in Foods, National Academy of Sciences, Washington, D.C. |
(1973) pp. 254-275. |
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Shane B, Snell E E |
Metabolism of 5'-deoxypyridoxine in rats: 5'-deoxypyridoxine 4'-sulphate as a major urinary metabolite. |
Biochem. Biophys. Res. Comm. |
(1975) 66: 1294-1300. |
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Nishijima M, Kanmuri M, Takahashi S, Kamimura H, Nakazato M, Watari Y, Kimura Y |
Survey of cyanide in almond.(in Japanese) |
Tokyo-To Eisei Kenkyusyo Nempo |
(1975) 26: 183-186. |
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Ozawa S, Okada Y |
Decrease of GABA levels and the appearance of a depolarization shift in thin hippocampal slice in vitro. |
Roberts E, Chase TN, Tower DB (eds) GABA in nervous system function. Raven Press, New York |
(1976) pp 449-454. |
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Nitsch C, Okada Y |
Decrease of GABA levels in different parts of the rabbit brain after treatment with methoxypyridoxine. |
Roberts E, Chase TN, Tower DB (eds) GABA in nervous system function. Raven Press, New York |
(1976) pp 455-460. |
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Bukin Yu V, Sergeev A V, Kondrat'eva G Ya |
Effects of some 2-alkyl and 4'-O-methyl analogs of pyridoxol on the activity of pyridoxal kinase from mouse liver.(In Russian) |
Biokhimiya |
(1976)41: 432-442. |
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Coburn S P, Mahuren J D |
In vivo metabolism of 4'-deoxypyridoxine in rat and man. |
J. Biol. Chem. |
(1976)251: 1646-1652. |
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Oja S S, Kontro P |
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Taurine and neurological disorders, Barbeau A, Huxtable R J (eds) Raven Press, New York |
(1978) pp181-200. |
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Mizuno N, Kawakami K, Morita E |
Competitive inhibition between 4'-substituted pyridoxine analogues and pyridoxal. For pyridoxal kinase from mouse brain. |
J Nutr Sci Vitaminol. |
(1980) 26: 535-543. |
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Takagaki, G. |
Neurobiochemistry. (in Japanese). |
Kyoritsu Shuppan, Tokyo, |
(1981) pp. 72-75 (Kyoritsu Zensho, vol. 238) |
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Wada K, Ishigaki S, Ueda K, Sakata M, Haga M |
An antivitamin B6, 4'-methoxypyridoxine from the seed of Ginkgo biloba L. |
Chem Pharm Bull. |
(1985)33: 3555-3557. |
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Wada K |
Ginkgo biloba and Gin-nan food poisoning.(in Japanese) |
Kagaku To Yakugaku No Kyoshitsu |
(1986) 95: 79-82. |
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Take, Y., Wada, K., Sasaki, K., Sakata, M., Haga, M. |
Studies on Plant Food Poisoning. (2) Food Poisoning by Ginkgo Seeds and Antivitamin B6. |
The 106th Annual Meeting of Pharmaceutical Society of Japan, Chiba |
April 1986. |
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Take Y, Sasaki K, Wada K, Sakata M, Haga M |
Studies on the plant food poisoning III. The determination of toxic principle, 4'-methoxypyridoxine in the seed of Ginkgo biloba with HPLC. |
The107th Annual meeting of Pharamaceutical society of Japan, Kyoto. |
(1987) |
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Wada K, Ishigaki S, Ueda, K Take, Y, Sasaki K, Sakata M, Haga, M |
Studies on the constitution of edible and medicinal plants.I. Isolation and Identification of 4-O-methylpyridoxine, toxic principle from the seed of Ginkgo biloba L. |
Chem Pharm Bull. |
(1988) 36: 1779-1782. |
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Ishizawa J, Tsujikawa A, Ohashi T |
Gin-nan food poisoning. (in Japanese) |
Gekkan Yakuji |
(1990)32: 2444-2445. |
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Minami M, Yanai A, Endo T, Hamaue M, Hamaue N,Monma Y, Wada K, Haga M, Morii K, Yoshioka M, Saito H |
Convulsion induced by 4-O-methylpyridoxine, from the seed of the Ginkgo biloba L., in guinea pigs and rats. |
Life Sci. Adv. |
(1990) 9: 107-115. |
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Huh H, Staba E J |
The botany and chemistry of Ginkgo biloba L. |
J Herbs, Spices Med. Plants |
(1992) 1: 91-124. |
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Higuchi, H., Kinjo, J., Nohara, T. |
An arrhythmic-inducing glycoside from Albizzia julibrissin Durazz. |
Chem. Pharm. Bull. |
(1992)40: 829-831. |
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Yagi M, Wada K, Sakata M, Kokubo M, Haga M |
Studies on the constituents of edible and medicinal plants. IV. Determinationof 4-O-methylpyridoxine in serum of the patient withgin-nan food poisoning. (In Japanese with English abstract) |
Yakugaku Zasshi |
(1993) 113: 596-599. |
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Wada, K., Sasaki, K., Miura, K., Yagi, M., Kubota, Y., Matsumoto, T., Haga, M. |
Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. |
Biol. Pharm. Bull. |
(1993)16: 210-212. |
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Hirai H, Okada Y |
Ipsilateral corticotectal pathway inhibits the formation of long-term potentiation (LTP) in the rat suprior colliculus through GABAergic mechanism. |
Brain Res. |
(1993) 629: 23-30. |
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Sasaki K.,Wada, K., Haga, M., Hatta, S., Ohshika, H. |
Studies on the constituents of edible and medicinal plants. V. Biological active components in Ginkgo leaves (3). Anticonvulsant effects of bilobalide and the effects of bilobalide on metabolizing enzymes. |
The 114th Annual Meeting of Pharmaceutical Society of Japan, Tokyo, Mar. 1994. |
(1994) |
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Sasaki K., Hatta S., Wada K., Ohshika H., Haga M. |
Anticonvulsant activity of bilobalide, a sesquiterpene in Ginkgo biloba L. leaves, against chemical-induced and electroshock-induced convulsions in mice. |
Res. Com. Biol. Psychol. Psychiatry |
(1995) 20: 145- 156. |
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Wada K. |
Studies on the constituents of edible and medicinal plants to affect the metabolizing system in mammals.(in Japanese with English abstract) |
Natural Medicines |
(1996) 50: 195-203. |
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Wada K, Sasaki K, Miura K, Yagi M, Kubota Y, Matsumoto T, Haga M |
Isolation of billobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. |
Biol. Pharm. Bull. |
(1996) 16: 210-212. |
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Arenz, A., Klein, M., Fiehe, K., Gros, J., Drewke, C., Hemscheidt, T., and Leistner, E. |
Occurrence of Neurotoxic 4'-O-Methylpyridoxine in Ginkgo biloba Leaves, Ginkgo Medications and Japanese Ginkgo Food. |
Planta Med. |
(1996)62:548-551. |
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Tsuge, H., Suganuma, K., Sasaki, S. |
Vitamin B-6 derivatives found in Ginkgo nuts (Ginkgo biloba L. Seeds). (in Japanese). |
Vitamins |
(1996)70: 561-562 |
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Wada K. Haga M. |
Food Poisoning by Ginkgo biloba Seeds. |
In T. Hori, R. W. Ridge, W.Tulecke, P. Del Tredici, J. Treouillaux-Guiller H. Tobe (eds.), Ginkgo biloba-A Global Treasure, Springer-Verlag Tokyo, Japan |
(1997)pp. 309-321. |
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Yoshimura, I., Hayata, M., Yamasaki, F., Mori, H. |
Natural toxin (in Japanese). |
Kyusei Chudoku Joho File, Hirokawa Publishing Co., Tokyo |
(1996) p. 699 |
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Wada K. |
Food poisoning by Ginkgo Seeds:The Role of 4-O-methylpyridoxine |
In Teris A. van Beek ed. GINKGO BILOBA, Harwood academic publishers |
(2000)pp.453-465. |
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M.Fujisawa, Y.Hori, M.Nakajima, K.Shimada, H.Yoshikawa, K.Wada |
Gas Chromatography-Mass Spectrometry Analysis of 4-O-Methylpyridoxine (MPN) in the Serum of Patients with Ginkgo Seed Poisoning |
J. Anal. Toxicol. |
(2002) 26,138-143. |
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Y. Hori, M. Fujisawa, K. Shimada, A. Oda, S. Katsuyama, K.Wada |
Rapid analysis of 4-O-methylpyridoxine in the serum of patients with Ginkgo biloba seed poisoning by ion-pair high performance liquid chromatography |
Biol. Pharm. Bull |
(2004)27(4), 486-491 |
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