江本研究室

Publication

2024

• Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor. Kazuhiro Kato, Hironobu Yasui, Hideo Sato-Akaba, Miho C. Emoto, Hirotada G. Fujii,Maciej M. Kmiec, Periannan Kuppusamy, Yuki Mizuno, Yuji Kuge, Masaki Nagane, Tadashi Yamashita, Osamu Inanami. Free Radic Biol Med.2024; .DOI : .
　　　　

　　　　

2023

• Effect of relative configuration of TEMPO-type nitroxides on ascorbate reduction. Risa Azuma, Toshihide Yamasaki, Miho C Emoto, Hideo Sato-Akaba, Kohei Sano, Masayuki Munekane, Hirotada G Fujii, Takahiro Mukai. Free Radic Biol Med.2023;194:114-122 .DOI : 10.1016/j.freeradbiomed.2022.11.033.
　　　　

2021

• Three-dimensional electron paramagnetic resonance imaging of mice using ascorbic acid sensitivenitroxide imaging probes. Hideo Sato-Akaba, Miho C Emoto, Ken-Ichi Yamada, Hisashi Koshino, Hirotada G Fujii. Free Radical Research.2021;55:950-957 .DOI : https://doi.org/10.1080/10715762.2021.1991918
　　　　　
• Early detection of redox imbalance in the APPswe/PS1dE9 mouse model of Alzheimer’s disease by in vivo electron paramagnetic resonance imaging. Emoto MC, Sato-Akaba H, Hamaue N, Kawanishi K, Koshino H, Shimohama S, Fujii HG. Free Radical Biology and Medicine.2021;172:9-18.DOI : https://doi.org/10.1016/j.freeradbiomed.2021.05.035
• Design and fabrication of compact arrayed magnet for biological EPR imaging. Hideo Sato-Akabaa, Yuki Okadab, Kentaro Tsujib, Miho C. Emoto and Hirotada G. Fujii. Applied Magnetic Resonance 2021;52(8):1017-1029.DOI : https://doi.org/10.1007/s00723-020-01256-4
　　　　

2019

• Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress. Yokokawa K, Iwahara N, Hisahara S, Emoto MC, Saito T, Suzuki H, Manabe T, Matsumura A, Matsushita T, Suzuki S, Kawamata J, Sato-Akaba H, Fujii HG, Shimohama S. J Alzheimers Dis. 2019;72:867-884. doi:10.3233/JAD-190817.
• Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease. Saito T, Hisahara S, Iwahara N, Emoto MC, Yokokawa K, Suzuki H, Manabe T, Matsumura A, Suzuki S, Matsushita T, Kawamata J, Sato-Akaba H, Fujii HG, ShimohamaS. Free Radical Biology and Medicine. 2019;145:20-32. doi:10.1016/j.freeradbiomed.2019.09.014.
• Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy. Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S, Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S. J Alzheimers Dis. 2019;67(3):1079-1087. doi: 10.3233/JAD-180985.
• Brain Redox Imaging Using In Vivo Electron Paramagnetic Resonance Imaging and Nitroxide Imaging Probes. Hirotada G. Fujii, Miho C. Emoto and Hideo Sato-Akaba magnetochemistry 2019:5(1) 　doi:10.3390/magnetochemistry5010011
• Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model. Emoto MC, Sato-Akaba H, Matsuoka Y, Yamada KI, Fujii HG. Neuroscience Lett.2019;690:6-10　doi: 10.1016/j.neulet.2018.10.001

2018

• Synthesis and Evaluation as a Blood-Brain Barrier-Permeable Probe of 7-N-(PROXYL-3-yl-methyl)theophylline. Emoto MC, Sasaki K, Maeda K, Fujii HG, Sato S. Chem Pharm Bull (To 2018;66(9):887-891. doi: 10.1248/cpb.c18-00333.

2017

• Design and testing of a 750MHz CW-EPR digital console for small animal imaging. Sato-Akaba Emoto MC, Hirata H, Fujii HG. J Magn Reson. 2017;284:48-58.　 doi: 10.1016/j.jmr.2017.09.008.
• Non-invasive imaging of the levels and effects of glutathione on the redox status of mouse brain using electron paramagnetic resonance imaging. Emoto MC, Matsuoka Y, Yamada KI, Sato-Akaba H, Fujii HG. Biochem Biophys Res Commun 2017;485(4):802-806 doi:10.1016/j.bbrc.2017.02.134.

2016

• Novel blood-brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging. Wang X, Emoto M, Miyake Y, Itto K, Xu S, Fujii H, Hirata H, Arimoto H. Bioorg Med Chem Lett. 2016;26(20):4947-4949 doi: 10.1016/j.bmcl.2016.09.010.
• Development of nitroxide-based theranostic compounds that act both as anti-inflammatory drugs and brain redox imaging probes in MRI. Emoto MC, Sato S, Fujii HG. Magn Reson Chem. 2016;54 (9):705–711 doi: 10.1002/mrc.4431.

2015

• Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe Emoto MC, Yamato M, Sato-Akaba, Yamada KI, Fujii HG. Neurosci Lett 2015. ;608:40-44　doi: 10.1016/j.neulet.2015.10.008
• Brain imaging in methamphetamine-treated mice using a nitroxide contrast agent for EPR imaging of the redox status and a gadolinium contrast agent for MRI observation of blood-brain barrier function. Emoto MC, Yamato M, Sato-Akaba H, Yamada K, Matsuoka Y, Fujii HG. Free Radical Research 2015; 49(8):1038-1047 doi:10.3109/10715762.2015.1040787
• Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging. Matsumura A, Emoto MC, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Sato-Akaba H, Fujii HG, Shimohama S Free Radic Biol Med. 2015; 85: 165-173. doi: 10.1016/j.freeradbiomed.2015.04.013.

2014

• Dynamic changes in the distribution and time course of blood-brain barrier-permeative nitroxides in the mouse head with EPR imaging: visualization of blood flow in a mouse model of ischemia Emoto MC, Sato-Akaba H, Hirata H, Fujii HG. Free Radic Biol Med 2014; 74:222-228 doi: 10.1016/j.freeradbiomed.2014.06.026.
• Synthesis of 15N-labeled 4-oxo-2,2,6,6-tetraethylpiperidine nitroxide for EPR brain imaging. X. Wang, M. Emoto, A. Sugimoto, Y. Miyake, K. Itto, M. Amasaka, S. Xu, H. Hirata, H. Fujii, and H. Arimoto. Tetrahedron Letters 2014; 55(13): 2146-2149 doi:10.1016/j.tetlet.2014.02.063

2013

• Four-channel surface coil array for sequential CW-EPR image acquisition. Enomoto A, Emoto M, Fujii H, Hirata H. J Magn Reson 2013; 234:21-29 doi: 10.1016/j.jmr.2013.06.007.
• Novel ascorbic acid-resistive nitroxide in a lipid emulsion: an efficient brain imaging contrast agent for MRI of small rodents. Emoto MC, Yamada K, Yamato M, Fujii HG. Neurosci Lett 2013; 546:11-15 doi: 10.1016/j.neulet.2013.04.044.
• Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging. Fujii HG, Sato-Akaba H, Emoto MC, Itoh K, Ishihara Y, Hirata H Magn Reson Imaging.2013; 31:130-138 doi: 10.1016/j.mri.2012.06.021.

2011

• A Novel ascorbic acid-resistive nitroxide in fat emulsion: An efficient brain imaging probe for in vivo EPR imaging of mouse. Emoto M, Mito F, Yamasaki T, Yamada KI, Sato-Akaba H, Hirata H, Fujii H Free Radical Research 2011; 45:1325-1332 doi: 10.3109/10715762.2011.618499.