研究実績
2024年
1. Kubota A, Imai S, Aoyagi R, Murase W, Terasaki M, Sugawara M, Takekuma Y, Kojima H. Immunoregulatory Effects of Elemental Diet and Its Ingredient, Tryptophan, via Activation of the Aryl Hydrocarbon Receptor in Mice. Int J Mol Sci. 2024 Mar 19;25(6):3448. doi: 10.3390/ijms25063448. PMID: 38542428;
2023年
1. Terasaki M, Tsuruoka K, Tanaka T, Maeda H, Shibata M, Miyashita K, Kanemitsu Y, Sekine S, Takahashi M, Yagishita S, Hamada A.
Fucoxanthin Inhibits Development of Sigmoid Colorectal Cancer in a PDX Model With Alterations of Growth, Adhesion, and Cell Cycle Signals. Cancer Genomics Proteomics. 2023. 686-705.
2. Tanaka T, Aoki R, Terasaki M.
Potential Chemopreventive Effects of Dietary Combination of Phytochemicals against Cancer Development. Pharmaceuticals (Basel). 2023. 16(11):1591.
3. Yasuda G, Kubota A, Okamoto K, Narumi K, Furugen A, Kato I, Mori A, Saito Y, Satoh T, Takahashi-Suzuki N, Iseki K, Kobayashi M.
Association between α-defensin 5 and the expression and function of P-glycoprotein in differentiated intestinal Caco-2 cells. Biopharm Drug Dispos. 2023. 358-364.
4. Murase W, Kubota A, Ikeda-Araki A, Terasaki M, Nakagawa K, Shizu R, Yoshinari K, Kojima H.
Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays.Toxicology. 2023. 494:153577.
5. Endo T, Kimura O, Terasaki M, Nakagun S, Kato Y, Fujii Y, Haraguchi K, Baker CS.
Carbon, nitrogen, and oxygen stable isotope ratios of striped dolphins and short-finned pilot whales stranded in Hokkaido, northern Japan, compared with those of other cetaceans stranded and hunted in Japan. Isotopes Environ Health Stud. 2023. 59(3):230-247.
2022年
1. Kubota A, Terasaki M, Sakuragi Y, Muromoto R, Ikeda-Araki A, Takada H, Kojima H.
Effects of benzotriazole UV stabilizers, UV-PS and UV-P, on the differentiation of splenic regulatory T cells via aryl hydrocarbon receptor.
Ecotoxicol Enviro Saf, 2022, 238, 113549.
2. Yasuda A, Wagatsuma M, Murase W, Kubota A, Kojima H, Ohta T, Hamada J, Maeda H, Terasaki M
Fucoxanthinol promotes apoptosis in MCF-7 and MDA-MB-231 cells by attenuating laminins-integrins axis.
Onco, 2022, 2, 145-163.
3. Terasaki M, Murase W, Kamakura Y, Kawakami S, Kubota A, Kojima H, Ohta T, Tanaka T, Maeda H, Miyashita K, Mutoh M
A biscuit containing fucoxanthin prevents colorectal carcinogenesis in mice
Nutrition and Cancer, In press.
4. Yokoyama R, Kushibiki A, Yamada S, Kubota A, Kojima H, Ohta T, Hamada J, Maeda H, Mutoh M, Terasaki M
Requirement of CLIC4 expression in human colorectal cancer cells for sensitivity to growth inhibition by fucoxanthinol
Cancer Genomics Proteomics, In press.
5. Terasaki M, Ono S, Hashimoto S, Kubota A, Kojima H, Ohta T, Tanaka T, Maeda H, Miyashita K, Mutoh M
Suppression of C-C chemokine receptor 1 is a key regulation for colon cancer chemoprevention in AOM/DSS mice by fucoxanthin
J Nutr Biochem, 2022, 99, 108871.
6. Narita T, Tsunematsu Y, Miyoshi N, Komiya M, Hamoya T, Fujii G, Yoshikawa Y, Sato M, Kawanishi M, Sugimura H, Iwashita Y, Totsuka Y, Terasaki M, Watanabe K, Wakabayashi K, Mutoh M
Induction of DNA damage in mouse colorectum by administration of colibactin-producing Escherichia coli, isolated from a colorectal cancer patient
In Vivo, 2022, 36(2), 628-634.
2021年
1. Sakuragi Y, Takada H, Sato H, Kubota A, Terasaki M, Takeuchi S, Ikeda-Araki A, Watanabe Y, Kitamura S, Kojima H.
An analytical survey of benzotriazole UV stabilizers in plastic products and their endocrine-disrupting potential via human estrogen and androgen receptors
Sci Total Environ. 2021, Dec 15;800:149374.
2. Murase W, Kamakura Y, Kawakami S, Yasuda A, Wagatsuma M, Kubota A, Kojima H, Ohta T, Takahashi M, Mutoh M, Tanaka T, Maeda H, Miyashita K, Terasaki M
Fucoxanthin prevents pancreatic tumorigenesis in C57BL/6J mice that received allogenic and orthotopic transplantations of cancer cells
Int J Mol Sci, 2021, 22, 13620.
3. Yokoyama R, Kubota A, Kojima H, Tanaka T, Mutoh M, Terasaki M
Detection of cells displaying high expression of CLIC4 in tumor tissue of patients with colorectal cancer
IN VIVO, 2021, 35, 3165-3173.
4. Kitagawa T, Kobayashi M, Ohta T, Terasaki M, Tsukamoto Y, Takai R, Ishizumi R, Uehara O, Nakagawa K, Akino K, Asaka M, Kuramitsu Y
Nine cases of SARS-CoV-2-PCR positive samples showed no increase of antibodies against SARS-CoV-2
IN VIVO, 2021, 35, 2947-2949.
5. Terasaki M, Kubota A, Kojima H, Maeda H, Miyashita K, Kawagoe C, Mutoh M, Tanaka T
Fucoxanthin and Colorectal Cancer Prevention
Cancers, 2021, 13, 2379.
6. Terasaki M, Nishizaka Y, Murase W, Kubota A, Kojima H, Kojoma M, Tanaka T, Maeda H, Miyashita K, Mutoh M, Takahashi M
Effect of Fucoxanthinol on Pancreatic Ductal Adenocarcinoma Cells from an N-Nitrosobis(2-oxopropyl)amine-initiated Syrian Golden Hamster Pancreatic Carcinogenesis Model
Cancer Genomics & Proteomics, 2021, 18, 407-423.
7. Terasaki M, Takahashi S, Nishimura R, Kubota A, Kojima H, Ohta T, Hamada J, Kuramitsu Y, Maeda H, Miyashita K, Takahashi M, Mutoh M
A marine carotenoid of fucoxanthinol accelerates the growth of human pancreatic cancer PANC-1 cells
Nutrition and Cancer, 2021, 16, 1-16.
8. Terasaki M, Inoue T, Murase W, Kubota A, Kojima H, Kojoma M, Ohta T, Maeda H, Miyashita K, Mutoh M, Takahashi M
A fucoxanthinol induces apoptosis in a pancreatic intraepithelial neoplasia cells
Cancer Genomics & Proteomics, 2021, 18(2), 133-146.
9. Terasaki M, Hamoya T, Kubota A, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M
Fucoxanthin Prevents Colorectal Cancer Development in Dextran Sodium Sulfate-treated ApcMin/+ Mice
Anticancer Research, 2021, 41(3), 1299-1305
10. Yokoyama R, Kojima H, Takai R, Ohta T, Meda H, Miyashita K, Mutoh M, Terasaki M
Effect of CLIC4 on fucoxanthinol-induced apoptosis in human colorectal cancer cells
Nutr Cancer, 2021, 73, 889-898.
11. Endo T, Kimura O, Terasaki M, Kobayashi M
Body length, stable carbon, and nitrogen isotope ratios and mercury levels in common minke whales stranded along the coast of hokkaido, Japan.
Aquatic Mammals 2021, 47(1), 86-95.
12. Takeda F, Oda M, Terasaki M, Kubota A, Asada K, Ichimura Y, Kojima H, Saitoh H
Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury
Drug Metab Pharmacokinet, 2021, 40, 100411
13. Takeda F, Oda M, Terasaki M, Ichimura Y, Kojima H, Saitoh H
Downregulated expression of intestinal P-glycoprotein in rats with cisplatin-induced acute kidney injury causes amplification of its transport capacity to maintain “gatekeeper” function
Toxicol Appl Pharmacol, 2021, 423, 115570
14. Kubota A, Terasaki M, Takai R, Kobayashi M, Muromoto R, Kojima H.
5-Aminosalicylic acid, a weak agonist for aryl hydrocarbon receptor that induces splenic regulatory T cells
Pharmacology. 2021, Dec 16, 1-7.
15. Yasuda G, Kobayashi M, Kubota A, Narumi K, Furugen A, Saito Y, Satoh T, Suzuki N, Iseki K.
Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin
Biol Pharm Bull. 2021, 44(2):275-278.
2020年
1. Kenda M, Kuželički NK, Iida M, Kojima H, Dolenc MS
Triclocarban, Triclosan, Bromochlorophene, Chlorophene and Climbazole on Nuclear Receptors: an in-Silico and in-Vitro Study
Environmental Health Perspectives, 2020, 128, 107005.
2. Park C, Song H, Choi J, Sim S, Kojima H, Park M, Iida M, Lee YJ
The mixture effects of bisphenol derivatives on estrogen receptor and androgen receptor.
Environmental Pollution 2020, 260, 114036.
3.Tsugoshi Y, Watanabe Y, Tanikawa Y, Inoue C, Sugihara K, Kojima H, Kitamura S
Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes.
Chemico-Biological Interactions, 2020, 327, 109148.
4. Terasaki M, Uehara O, Ogasa S, Sano T, Kubota A, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M
Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS-treated mice.
Carcinogenesis, 2021, 42(2), 210-219.
5. Terasaki M, Kimura R, Kubota A, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M
Continuity of tumor microenvironmental suppression in AOM/DSS mice by fucoxanthin may be able to track with salivary glycine.
IN VIVO, 2020, 34(6), 3205-3115.
6. Yokoyama R, Kojima H, Takai R, Ohta T, Maeda H, Miyashita K, Mutoh M, Terasaki M
Effects of CLIC4 on Fucoxanthinol-induced Apoptosis in Human Colorectal Cancer Cells.
Nutrition and Cancer, 2021, 73(5), 889-898.
7. Terasaki M, Ikuta M, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M
Dietary fucoxanthin induces anoikis in colorectal adenocarcinoma by suppressing integrin signaling in a murine colorectal cancer model.
Journal of Clinical Medicine 2020, 9(1), 90-104.
8. Terasaki M, Kuramitsu Y, Kojoma M, Kim SY, Tanaka T, Maeda H, Miyashita K, Kawagoe C, Kohno S, Mutoh M
High fucoxanthin wakame (Undaria pinnatifida) prevents tumor microenvironment formation in an AOM/DSS mouse carcinogenic model.
Journal of Functional Foods 2020, 64, 103709.
9. Kubota A, Imai S, Momo K, Sugawara M, Takekuma Y
Survey Based on Claims Data of New Control-Released Budesonide for Crohn’s Disease
The Journal of Community Pharmacy and Pharmaceutical Sciences 2020, 13, 54-61.
2019年
1. Watanabe Y, Hattori S, Fujino C, Tachibana K, Kojima H, Yoshinari K, Kitamura S
Effects of benzotriazole ultraviolet stabilizers on rat PXR, CAR and PPARalpha transcriptional activities.
Fundamental Toxicological Sciences 2019, 6(2): 57-63
2. Kojima H, Takeuchi S, Sanoh S, Okuda K, Kitamura S, Uramaru N, Sugihara K, Yoshinari K
Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors.
Toxicology 2019, 413: 48-55.
3. Fujino C, Watanabe Y, Sanoh S, Hattori S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S
Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARα-mediated transcriptional activation.
Food and Chemical Toxicology 2019 [doi: 10.1016/j.fct.2019.110792]
4. Fujino C, Watanabe Y, Sanoh S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.
Activation of PXR, CAR and PPARa by pyrethroid pesticides and effect of the metabolism by rat liver microsomes
Heliyon 2019, 5(9), e02466.
5. Takeuchi S, Tanaka-Kagawa T, Saito I, Kojima H, Jinno H.
Distribution of 58 semi-volatile organic chemicals in the gas phase and three particle sizes in indoor air and house dust in residential buildings during the hot season in Japan.
BPB Reports 2019, 2(6), 91098.
6. Abe T, Itoh T, Terasaki M
Total Synthesis of Fontanesine B and its isomer: Their antiproliferative activity against human colorectal cancer cells.
Helvetica Chimica Acta 2019, 102, e1900116.
7. Terasaki M, Masaka S, Fukada C, Houzaki M, Endo T, Tanaka T, Maeda H, Miyashita K, Mutoh M
Salivary glycine is a significant predictor for the attenuation of polyp and tumor microenvironment formation by fucoxanthin in AOM/DSS mice.
IN VIVO 2019, 33: 365-374.
8. Terasaki M, Iida T, Kikuchi F, Tamura K, Endo T, Kuramitsu Y, Tanaka T, Maeda H, Miyashita K, Mutoh M
Fucoxanthin potentiates anoikis in colon mucosa and prevents carcinogenesis in AOM/DSS model mice.
The Journal of Nutritional Biochemistry 2019, 64: 198-205.
9. Terasaki M, Matsumoto N, Hashimoto R, Endo T, Maeda H, Hamada J, Osada K, Miyashita K, Mutoh M
Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, withan anti-tumor predictor of glycine.
Journal of Clinical Biochemistry and Nutrition 2019, 64: 52-58.
10. Tamura S, Narita T, Fujii G, Miyamoto S, Hamoya T, Kurokawa Y, Takahashi M, Miki K, Matsuzawa Y, Komiya M, Terasaki M, Yano T, Mutoh M
Inhibition of NF-kappaB transcriptional activity enhances fucoxanthinol-induced apoptosis in colorectal cancer cells.
Genes Environment 2019. [doi: 10.1186/s41021-018-0116-1]
11. Komatsu T, Katsuyama S, Takano F, Okamura T, Sakurada C, Tsuzuki M, Ogawa K, Kubota A,, Morinaga O, Tabata K, Sakurada T
Possible Involvement of the μ Opioid Receptor in the Antinociception Induced by Sinomenine on Formalin-Induced Nociceptive Behavior in Mice
NEUROSCIENCE LETTERS 2019, 699:103-108.
2018年
1. 武内伸治、高橋正幸、藤本啓、佐藤正幸、小島弘幸
危険ドラッグ検査の化学分析を補完する薬物受容体アッセイ及び植物片DNA解析の有用性評価
北海道公衆衛生学雑誌 32(2) 印刷中 2018年
2. Kojima H, Takeuchi S, Iida M, Nakayama SF, Shiozaki T
A sensitive, rapid and simple DR-EcoScreen bioassay for the determination of PCDD/Fs and dioxin-like PCBs in environmental and food samples.
Environmental Science and Pollution Research 2018, 25: 1701-1712.
3. Takeuchi S, Tanaka-Kagawa T, Saito I, Kojima H, Jin K, Satoh M, Kobayashi S, Jinno H
Differential determination of plasticizers and organophosphorus flame retardants in residential indoor air in Japan.
Environmental Science and Pollution Research 2018, 25: 1713-1720.
4. Kuhara K, Tokuda K, Kitagawa T, Baron B, Tokunaga M, Harada K, Terasaki M, Uehara O, Ohta T, Takai R, Hamada JI, Kobayashi M, Shimo T, Nagayasu H, Kuramitsu Y
CUB domain-containing protein 1 (CDCP1) is down-regulated by active hexose-correlated compound in human pancreatic cancer cells.
Anticancer Research 2018, 38, 6107-6111.
5. Terasaki M, Mima M, Kudoh S, Endo T, Maeda H, Hamada J, Osada K, Miyashita K, Mutoh M
Glycine and succinic acid are effective indicators of the suppression of epithelial-mesenchymal transition by fucoxanthinol in colorectal cancer stem-like cells.
Oncology Reports 2018, 40: 414-424.
6. Terasaki M, Ogawa Y, Endo T, Maeda H, Hamada J, Osada K, Miyashita K, Mutoh M.
Glycine is a predictor for a suppressive effect of fucoxanthinol on colonosphere formation under hypoxia.
Anticancer Research 2018, 38: 2169-2179.
7. Abe T, Terasaki M
Synthesis of Phaitanthrin E and tryptanthrin through amination/cyclization cascade.
Helvetica Chimica Acta 2018, 101, e1700284.
8. Kubota A, Kobayashi M, Sarashina S, Takeno R, Okamoto K, Narumi K, Furugen A, Suzuki Y, Takahashi N, Iseki K.
Reishi mushroom Ganoderma lucidum Modulates IgA production and alpha-defensin expression in the rat small intestine.
J Ethnopharmacol 2018, 214, 240-243.
9. Kubota A, Kobayashi M, Sarashina S, Takeno R, Yasuda G, Narumi K, Furugen A, Takahashi-Suzuki N, Iseki K.
Gamma-Aminobutyric Acid (GABA) Attenuates Ischemia Reperfusion-Induced Alterations in Intestinal Immunity.
Biol Pharm Bull2018, 41(12), 1874-1878.
2017年
1. 武内伸治、小林 智、小島弘幸、八坂通泰
シラカバ花粉飛散量予測を目的とするデジタルカメラを用いたカバノキ属雄花序着花量の調査法開発
北海道公衆衛生学雑誌 2017, 31(2): 101-105.
2. Zwart N, Andringa D, de Leeuw WJ, Kojima H, Iida M, Houtman C, de Boer J, Kool J, Lamoree M, Hamers T
Improved androgen specificity of AR-EcoScreen by CRISPR based glucocorticoid receptor knockout.
Toxicology in Vitro 2017, 45: 1-9.
3. Takahashi M, Muromoto R, Kojima H, Takeuchi S, Kitai Y, Kashiwakura J, Matsuda T
Biochanin A enhances RORγ activity through STAT3-mediated recruitment of NCOA1.
Biochemical and Biophysical Research Communications 2017, 489: 503-508.
4. Takeuchi S, Anezaki K, Kojima H
Effects of unintentional PCBs in pigments and chemical products on transcriptional activity via aryl hydrocarbon and nuclear hormone receptor.
Environmental Pollution 2017, 227: 306-313.
5. Abe T, Takahashi M, Kano M, Amaike Y, Ishii C, Maeda K, Kudo Y, Morishita T, Hosaka T, Sasaki T, Kodama S, Matsuzawa A, Kojima H, Yoshinari K
Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.
Archives of Toxicology 2017, 91: 2365-2374.
6. 増田茜、増田雅美、川野拓歩、橘内陽子、中山晴香、中島宏之、小島弘幸、北村繁幸、浦丸直人、保坂卓臣、佐々木崇光、吉成浩一
肝細胞肥大の毒性学的特徴の解明に向けた農薬のラット反復投与毒性試験結果のデータベース構築
薬学雑誌 2017, 135(5): 611-622.
7. Terasaki M, Kawagoe C, Ito A, Kumon H, Narayan B, Hosokawa M, Miyashita K
Spatial and seasonal variations in the biofunctional lipid substances (fucoxanthin and fucosterol) of the laboratory-grown edible Japanese seaweed (Sargassum horneri Turner) cultured in the open sea
Saudi Journal of Biological Sciences 2017, 24(7): 1475-1482.
8. Terasaki M, Maeda H, Miyashita K, Mutoh M
Induction of Anoikis in Human Colorectal Cancer Cells by Fucoxanthinol.
Nutrition and Cancer 2017, 69(7): 1043-1052.
9. Endo T, Kimura O, Terasaki M, Fujii Y, Haraguchi K, Ohta C, Koga N, Kato Y
Growth-related changes in non-essential and essential metals in the liver of star-spotted smooth-hounds (dogfish) Mustelus manazo from the northern region of Japan.
Marine Environmental Research 2017, 131: 156-161.
10. Terasaki M, Maeda H, Miyashita K, Tanaka T, Miyamoto S, Mutoh M
A marine bio-functional lipid, fucoxanthinol, attenuates human colorectal cancer stem-like cell tumorigenicity and sphere formation.
Journal of Clinical Biochemistry and Nutrition 2017, 61(1): 25-32.
11. Kubota A, , Shindo H, Fukushima Y, Komatsu T, Sakurada T, Yasuda T, Fushiya S, Kondo Y, Sakurada C, Takano F
Effects of Kampo Extract Boiogito and Its Alkaloid Sinomenine on Nociceptive Pain in Mouse Models
Pharmacometrics 2017, 92, 83-89
研究概要
<研究内容について>
【環境化学物質による核内受容体を介した生体影響評価に関する研究】
（１）レポーター遺伝子アッセイ法を用いた環境化学物質における核内受容体活性の探索：ヒトは身の回りに存在する多種類の化学物質に日々曝露されています。核内受容体は、化学物質応答性の転写調節因子であり、発生・生殖・恒常性・代謝などの生命活動の根幹に係わる遺伝子発現に関与しています。本研究では、高感度なレポーター遺伝子アッセイ法を用いて環境化学物質の化学構造と核内受容体活性の関係を明らかにすることで、内分泌かく乱作用などの毒性評価を行っています。
（２）免疫系細胞に存在する核内受容体の機能解明及び環境化学物質による活性影響：炎症性疾患やがん疾患の増悪に係わる核内受容体のレポーター遺伝子アッセイ法を構築しています。環境化学物質において活性探索を行うことでサイトカイン産生など免疫系への毒性影響を調べています。
（３）男性ホルモン受容体（AR）およびダイオキシン受容体（DR）の遺伝子導入細胞株を用いたヒト血液での受容体活性検出法の開発：我々が既に開発した高感度細胞株を用いて、ヒト血中の化学物質によるAR及びDR活性の検出法開発を行っています。将来的に、妊娠母体血や臍帯血を用いた疫学調査に活用し、胎児期において人体を汚染する化学物質の受容体活性と生後の疾患発症との関係を明らかにしたいと思っています。
【食品及び食品由来成分によるがん予防】
がんは未だに人類の命を脅かす重大な疾患であり、予防法や治療法の開発は急務です。近年、我が国の罹患者数と死亡者数が増加傾向にある大腸がん、膵がん及び乳がんは、肥満等の生活習慣病が主なリスク因子の一つです。そのため、食生活の改善ががん予防の有望な方法の一つと考えられております。
食品中には、ビタミン、ポリフェノール、カロテノイド等の機能性物質が豊富に含まれております。本研究では、食品に豊富に含まれている色素成分の一つ「カロテノイド」のがん予防効果に着目しています。幾つかのカロテノイドは緑黄色野菜や海藻に豊富に含まれており、カロテノイドを日常的に食卓に取り入れた食生活によりがんを予防できる可能性があります。本研究では、大腸がん、膵がん及び乳がんの発がんモデルマウスや培養系がん細胞を用いて、カロテノイドによるモデル動物のがん予防効果の分子機序や、がん細胞アポトーシス誘導作用の分子機序を、蛍光・共焦点顕微鏡、セルソーター、マイクロアレイ、次世代シーケンサー等の最先端の分析機器を用いて解明することを目指しています。
マイクロアレイを用いたがん細胞の遺伝子網羅解析の様子
【環境因子による炎症性腸疾患予防制御機構の解析】
炎症性腸疾患（IBD）は、近年患者数の増えている原因不明の慢性炎症性疾患です。2000年代に入り、患部へ薬物を到達させるドラッグデリバリーシステムの進歩や、抗体医薬品の登場など治療は大きく進歩しました。発病には遺伝因子、環境因子などが複雑に関わると考えられていますが、原因の解明には至っていません。本研究では、環境因子（食事や衛生環境）が与える影響を細胞実験（in vitro）と IBD モデル動物（in vivo）の両面から解析します。加えて、大規模レセプトデータを用いた実臨床のデータを活用し（対象患者数3万人程度）、IBD 治療のリアルワールドデータ解析を併行して行っています。