研究実績
最近３年間の研究業績
1) Facile Synthesis of Indole 3-Acetic Acid and Azaindole 3-Acetic Acid Derivatives, Koji Yamada, Mariko Ohta, Go Kitamura, Suzuka Tsutsumiguchi, and Takahide Nishi, Tetrahedron, 2023, 135, 133328.
2) Practical Synthetic Method of Ogipeptin Derivatives, Shingo Takiguchi and Takahide Nishi, Synlett, 2023, 34, 277.
3) Practical Synthesis of 7-Azaserotonin and 7-Azamelatonin, Ren Fukuya, Koji Yamada and Takahide Nishi, Synlett, 2022, 33, 2033.
4) Total Synthesis and Structural Elucidation of Ogipeptins, Shingo Takiguchi, Yuki Hirota-Takahata and Takahide Nishi, Org. Lett., 2022, 24, 4935.
5) [3 + 2] cycloaddition of 1-(4-Methoxybenzyl)indoles and azaindoles with nitrile oxides, Reina Kimura, Yoshihiro Sato, Kazuhiro Morisaki and Takahide Nishi, Tetrahedron, 2022, 113, 132760.
6) Application of the advanced Marfey’s method for the determination of the absolute configuration of ogipeptins, Shingo Takiguchi, Yuki Hirota-Takahata and Takahide Nishi, Tetrahedron Lett., 2022, 96, 153760.
7) Synthesis and Applications of 3-Bromo-2-hydroxy-1-tosylazaindolines, Koji Yamada, Naoki Mishima, Kanae Saito and Takahide Nishi, Tetrahedron, 2021, 97, 132404.
8) Syntheses and Antimicrobial Activities of Ogipeptin Derivatives, Shingo Takiguchi, Hidehito Homma, Tetsunori Fujisawa, Yuki Hirota-Takahata, Yasunori Ono, Masaaki Kizuka, Yuki Ishii, Satomichi Yoshimura and Takahide Nishi, Bioorg. Med. Chem. Lett., 2021, 42, 128093.
研究概要
西 剛秀、山田康司、坪郷 哲
当研究室は、『新しい反応の開発とそれを応用した生理活性天然物の合成』をメインテーマとして研究を展開しています。特に医薬品や生体分子、アルカロイドの基本骨格として重要な芳香族複素環のインドールにフォーカスを当てて、試行錯誤しながらものづくり（合成）を行っています。