【英文】

45. Knockdown of long noncoding RNA dreh facilitates cell surface GLUT4 expression and glucose transport through the involvement of vimentin in 3T3-L1 adipocytes. *Takahashi N, Kimura AP, Ohmura K, Naito S, Yoshida M, Ieko M. Gene 735: 144404, 2020. (*Corresponding Author)

44. Dreh, a long noncoding RNA repressed by metformin, regulates glucose transport in C2C12 skeletal muscle cells. *Takahashi N, Kimura AP, Otsuka K, Ohmura K, Naito S, Yoshida M, Ieko M. Life Sciences 236: 116909, 2019.  (*Corresponding Author)

43. Lupus anticoagulant-hypothrombocytonemia syndrome and similar diseases: experiences at a single center in Japan. Ieko M, Yoshida M, Naito S, Ohmura K, Satoh Y, Takahashi N. International Journal of Hematology 110: 197-204, 2019.

42. A novel testis-specific long noncoding RNA, Tesra, activates the Prss42/Tessp-2 gene during mouse spermatogenesis. Satoh Y, Takei N, Kawamura S, Takahashi N, Kotani T, Kimura AP. Biology of Reproduction 100: 833-848, 2019.

41. Basic evaluation of the newly developed "Lias Auto P-FDP" assay and the influence of plasmin-α2 plasmin inhibitor complex values on discrepancy in the comparison with "lias Auto D-Dimer Neo" assay. Kumano O, Ieko M, Komiyama Y, Naito S, Yoshida M, Takahashi N, Ohmura K, Hayasaki J, Hayakawa M. Clinical Laboratory 64: 433-442, 2018.

40. Sarcolipin expression is repressed by endoplasmic reticulum stress in C2C12 myotubes. *Takahashi N, Kimura AP, Naito S, Yoshida M, Kumano O, Suzuki T, Itaya S, Moriya M, Tsuji M, Ieko M. Journal of Physiology and Biochemistry 73: 531-538, 2017. (*Corresponding Author)

39. New formulas for mixing test to discriminate between lupus anticoagulant and acquired hemophilia A. Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N, Suzuki T, Komiyama Y. Thrombosis Research 143: 53-57, 2016.

38. Profiles of direct oral anticoagulants and clinical usage-dosage and dose regimen differences. Ieko M, Naitoh S, Yoshida M, Takahashi N. Journal of Intensive Care 4: 19, 2016.

37. The production of coagulation factor VII by adipocytes is enhanced by tumor necrosis factor-α or isoproterenol. *Takahashi N, Yoshizaki T, Hiranaka N, Kumano O, Suzuki T, Akanuma M, Yui T, Kanazawa K, Yoshida M, Naito S, Fujiya M, Kohgo Y, Ieko M. International Journal of Obesity 39: 747-754, 2015. (*Corresponding Author)

36. Lupus anticoagulant diagnosis in activated partial thromboplastin time mixing test: optimization of the index of circulating anticoagulant cut-off value. Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N, Suzuki T, Aoki T. Clinical Laboratory 60: 2115-2118, 2014.

35. Verification of the guidelines for lupus anticoagulant detection: Usefulness of index for circulating anticoagulant in APTT mixing test. Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N, Suzuki T Aoko T. Thrombosis Research 134: 503-509, 2014.

34. An NA-deficient 2009 pandemic H1N1 influenza virus mutant can efficiently replicate in cultured cells. Inoue E, Ieko M, Takahashi N, Osawa Y, Okazaki K. Archives of Virology 159:797-800, 2014.

33. Index of circulating anticoagulant cut-off value establishment in activated partial thromboplastin time mixing test for lupus anticoagulant diagnosis. Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N, Aoki T. Journal of Thrombosis and Haemostasis 11: 1919-22, 2013.

32. Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes. *Takahashi N, Yoshizaki T, Hiranaka N, Suzuki T, Yui T, Akanuma M, Kanazawa K, Yoshida M, Naito S, Fujiya M, Kohgo Y, Ieko M. Biochemical and Biophysical Research Communications 431: 25-30, 2013. (*Corresponding Author)

31. APTT reagent with ellagic acid as activator shows adequate lupus anticoagulant sensitivity in comparison to silica-based reagent. Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N. Journal of Thrombosis and Haemostasis 10: 2338-2343, 2012.

30. Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response to a high-fat diet and free fatty acids. Motomura W, Yoshizaki T, Takahashi N, Kumei S, Mizukami Y, Jang SJ, Kohgo Y. Journal of Clinical Biochemistry and Nutrition 51: 163-169, 2012.

29. Phylogenetic analyses of pandemic influenza A (H1N1) virus in university students at Tobetsu, Hokkaido, Japan. Inoue E, Ieko M, Takahashi N, Osawa Y, Okazaki K. Microbiology and Immunology 56: 273–279, 2012.

28. Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes. *Takahashi N, Yoshizaki T, Hiranaka N, Suzuki T, Yui T, Akanuma M, Oka K, Kanazawa K, Yoshida M, Naito S, Fujiya M, Kohgo Y, Ieko M. Biochemical and Biophysical Research Communications 415: 200-205, 2011. (*Corresponding Author)

27. Octreotide-treated diabetes accompanied by endogenous hyperinsulinemic hypoglycemia and protein-losing gastroenteropathy. *Takahashi N, Nagamine M, Fukuda M, Motomura W, Abiko A, Haneda M, Fujiya M, Ieko M, Kohgo Y. Case Reports in Medicine 2011: 381203, 2011. (*Corresponding Author)

26. A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-α in 3T3-L1 adipocytes. Tsuchiya Y, *Takahashi N, Yoshizaki T, Tanno S, Ohhira M, Motomura W, Tanno S, Takakusaki K, Kohgo Y, Okumura T. Biochemical and Biophysical Research Communications 382: 348-352, 2009. (*Corresponding Author)

25. LPS induces ADRP expression and lipid accumulation in the liver through Inhibition of fatty acid oxidation in mice. Ohhira M, Motomura W, Fukuda M, Yoshizaki T, Takahashi N, Tanno S, Wakamiya N, Kohgo Y, Kumei S, Okumura T. Journal of Gastroenterology 42: 969-978, 2007.

24. A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells. *Takahashi N, Nagamine M, Tanno S, Motomura W, Kohgo Y, Okumura T. Biochemical and Biophysical Research Communications 360: 244-250, 2007.  (*Corresponding Author)

23. Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet. Motomura W, Inoue M, Ohtake T, Takahashi N, Nagamine M, Tanno S, Kohgo Y, Okumura T. Biochemical and Biophysical Research Communications 340: 1111-1118, 2006.

22. Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice. Inoue M, Ohtake T, Motomura W, Takahashi N, Hosoki Y, Miyoshi S, Suzuki Y, Saito H, Kohgo Y, Okumura T. Biochemical and Biophysical Research Communications 336: 215-222, 2005.

21. A selective orexin-1 receptor antagonist, SB334867, blocks 2-DG-induced gastric acid secretion in rats. Yamada H, Takahashi N, Tanno S, Nagamine M, Takakusaki K, Okumura T. Neuroscience Letters 376: 137-142, 2005.

20. Involvement of MEK-ERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cell. Motomura W, Tanno S, Takahashi N, Nagamine M, Fukuda M, Kohgo Y, Okumura T. Biochemical and Biophysical Research Communications 332: 89-94, 2005.

19. Adiponectin acts in the brain to decrease body weight. Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS. Nature Medicine 10: 524-529, 2004.

18. A novel aminosterol reverses diabetes and fatty liver disease in obese mice. Takahashi N, Qi Y, Patel HR, Ahima RS. Journal of Hepatology 41: 391-398, 2004.

17. Regulation of Resistin Expression and Circulating Levels in Obesity, Diabetes, and Fasting. Rajala MW, Qi Y, Patel HR, Takahashi N, Banerjee R, Pajvani UB, Sinha MK, Gingerich RL, Scherer PE, Ahima RS. Diabetes 53: 1671-1679, 2004.

16. Growth arrest by troglitazone is mediated by p27Kip1 accumulation, which results from dual inhibition of proteasome activity and Skp2 expression in human hepatocellular carcinoma cells. Motomura W, Takahashi N, Nagamine M, Sawamukai M, Tanno S, Kohgo Y, Okumura T. International Journal of Cancer 108: 41-46, 2004.

15. Inhibition of cell invasion and morphological change by troglitazone in human pancreatic cancer cells. Motomura W, Nagamine M, Tanno S, Sawamukai M, Takahashi N, Kohgo Y, Okumura T. Journal of  Gastroenterology 39: 461-468, 2004.

14. PPARgamma ligand-induced apoptosis through a p53-dependent mechanism in human gastric cancer cells. Nagamine M, Okumura T, Tanno S, Sawamukai M, Motomura W, Takahashi N, Kohgo Y. Cancer Science 94: 338-343, 2003.

13. Divergent effects of leptin in mice susceptible or resistant to obesity. Takahashi N, Patel HR, Qi Y, Dushay J, Ahima RS. Hormone and Metabolic Research 34: 691-697, 2002.

12. Appetite suppression and weight reduction by a centrally active aminosterol. Ahima RS, Patel HR, Takahashi N, Qi Y, Hileman SM, Zasloff MA. Diabetes 51: 2099-2104, 2002.

11. Troglitazone Induces G1 Arrest by p27(Kip1) Induction That Is Mediated by Inhibition of Proteasome in Human Gastric Cancer Cells. Takeuchi S, Okumura T, Motomura W, Nagamine M, Takahashi N, Kohgo Y. Japanese Journal of Cancer Research (Currently known as: Cancer Science) 93: 774-782, 2002.

10. Activation of PPARgamma by troglitazone inhibits cell growth through the increase in p27Kip1 in human pancreatic carcinoma cells. Motomura W, Okumura T, Takahashi N, Obara T, Kohgo Y. Cancer Research 60: 5558-5564, 2000.

9. Increased serum leptin by cholecystitis in a diabetic patient. Moriya M, Okumura T, Motomura W, Takahashi N, Kitagawa T,Kohgo Y. Digestive Diseases and Sciences 45: 933-936, 2000.

8. Activation of PPARgamma inhibits cell growth andinduces apoptosis in human gastric cancer cells. Takahashi N, Okumura T, Motomura W, Fujimoto Y, Kawabata I, Kohgo Y. FEBS Letters 455: 135-139, 1999.

7. Stimulation of gastric acid secretion by centrally administered orexin- A in conscious rats. Takahashi N, Okumura T, Yamada H, Kohgo Y. Biochemical and Biophysical Research Communications 254: 623-627, 1999.

6. An inverse correlation between serum leptin levels and hemoglobin A1c in patients with non-insulin dependent diabetes mellitus. Moriya M, Okumura T, Takahashi N, Yamagata K, Motomura W, Kohgo Y. Diabetes Research and Clinical Practice 43: 187-191, 1999.

5. A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene. Takiguchi S, Takata Y, Takahashi N, Kataoka K, Hirashima T, Kawano K, Miyasaka K, Funakoshi A, Kono A. American Journal of Physiology - Endocrinology and Metabolism 274: E265-270, 1998.

4. Delayed gastric emptying by Helicobacter pylori lipopolysaccharide in conscious rats. Okumura T, Shoji E, Takahashi N, Wakebe H, Imagawa K, Kikuchi M, Kohgo Y. Digestive Diseases and Sciences 43: 90-94, 1998.

3. Helicobacter pylori lipopolysaccharide inhibits acid secretion in pylorus-ligated conscious rats. Ootsubo C, Okumura T, Takahashi N, Wakebe H, Imagawa K, Kikuchi M, Kohgo Y. Biochemical and Biophysical Research Communications 236: 532-527, 1997.

2. Gastric emptying in OLETF rats not expressing CCK-A receptor gene. Shoji E, Okumura T, Onodera S, Takahashi N, Harada K, Kohgo Y. Digestive Diseases and Sciences 42: 915-919, 1997.

1. Intracisternal injection of basic fibroblast growth factor reduces the severity of gastric mucosal lesions evoked by ethanol in rats. Watanabe Y, Okumura T, Onodera S, Takahashi N, Shoji E, Kohgo Y. Japanese Journal of Physiology 47: 231-233, 1997.