47) Expression of functional Stim1-mKO1 in rat submandibular acinar cells by retrograde ductal injection of an adenoviral vector.

Morita T, Tanimura A, Shitara A, Suzuki Y, Nezu A, Takuma T, Tojyo Y.

Arch Oral Biol.,56(11):1356-1365.

46) Visualization of Ins(1,4,5)P3 dynamics in living cells: two distinct pathways for Ins(1,4,5)P3 generation following mechanical stimulation of HSY-EA1 cells.

Nezu A., Tanimura A., Morita T., and Tojyo Y.

J Cell Sci., 123, 2292-2298, 2010.

45) Design and synthesis of indole derivatives of adenophostin A. A entry into subtype-selective IP3 receptor ligands.

Mochizuki T., Tanimura A., Nezu A., Ito M., Abe H., Ito Y., Arisawa M. and Shuto S.

Tetrahedron Lett., 51(6), 977-979, 2010.

44) Spontaneous oscillations in intracellular Ca2+concentration via purinergic receptors elicit transient cell swelling in rat parotid ducts.

Shitara A., Tanimura A., Sato A. and Tojyo Y.

Am. J. Physiol., 297(6):G1198-1205, 2009.

43) A novel Stim1-dependent, non-capacitative Ca2+ entry pathway is activated by B cell receptor stimulation and depletion of Ca2+ stores.

Morita T., Tanimura A., Baba Y., Kurosaki T., Tojyo Y.

J. Cell Sci., 122 (8):1220-1228, 2009.

42) The use of FRET based biosensors for the quantitative analysis of inositol 1,4,5-trisphosphate dynamics in calcium oscillations.

Tanimura A., Morita T., Nezu A., Shitara A., Hashimoto N., Tojyo Y.

J. Biol. Chem., 284:8910-8917, 2009.

41) A conserved hydrophobic tetrad near the C-terminus of the secretory Na+-K+-2Cl- contransporter (NKCC1) is required for its correct intracellular processing.

Nezu A., Parvin M.N., Turner R.J.

J. Biol. Chem., 284:6869-6876, 2009.

40) The clustering of inositol 1,4,5-trisphophate (IP3) receptors is triggered by IP3 binding and facilitated by depletion of the Ca2+ store.

Tojyo Y., Morita T., Nezu A., Tanimura A.

J. Pharmacol. Sci., 107:138-150, 2008.

39) Multi-photon microscopic imaging of rat parotid ducts demonstrates cellular heterogeneity in Ca2+ responsiveness.

Shitara A.,Tanimura A., Morita A., Nezu A., Tojyo Y.

Archs. Oral Biol., 52(11):1072-1078., 2007.

38) Synthesis and biological activity of metabolically stabilized cyclopentyl trisphosphate analogues of D-myo-Ins(1,4,5)P3.

Zhang L., Huang W., Tanimura A., Morita T., Harihar S., DeWald D.B., Prestwich G.D.

ChemMedChem, 2:1281-1289, 2007.

37) Odorant receptors directly activate phospholipase C/inositol-1,4,5-trisphophate coupled to calcium influx in Odora cells.

Liu G., Badeau R.M., Tanimura A., Talamo B.R.

J. Neurochem., 96:1591-1605, 2006.

36) 唾液分泌とシグナルトランスダクション

谷村　明彦、東城　庸介

日本薬理学雑誌, 127, 1249-255, 2006.

35) A novel fluorescent method employing the FRET-based biosensor "LIBRA" for the identification of ligands of the inositol 1,4,5-trisphosphate receptors.

Nezu A., Tanimura A., Morita T., Tojyo Y.

Biochim. Biophys. Acta., 1760(8):1274-1280, 2006.

34) Comparison of agonist-induced Ca2+ responses in rat submandibular acini and ducts.

Nezu A., Morita T., Tanimura A. and Tojyo Y.

Archs. Oral Biol., 50(6):585-592, 2005.

33) カルシウムシグナルと唾液分泌機能

東城　庸介

北海道医療大歯学雑誌, 24(1), 1-11, 2005.

32) Fluorescent biosensor for quantitative real-time measurements of inositol 1,4,5-trisphosphate in single living cells.

Tanimura A., Nezu A., Morita T., Turner R. J. and Tojyo Y.

J. Biol. Chem., 279: 38095-38098, 2004.

31) Signaling mechanisms involved in PAR-1-mediated interleukin-6 production by human gingival fibroblasts.

Tanaka N., Morita T., Nezu A., Tanimura A., Mizoguchi I. and Tojyo Y.

J. Pharmacol. Exp. Ther., 311: 778-786, 2004.

30) Functional analysis of the green fluorescent protein-tagged inositol 1, 4, 5-trisphosphate receptor type 3 in Ca2+ release and entry in DT40 B lymphocytes.

Morita T., Tanimura A., Nezu A., Kurosaki T. and Tojyo Y.

Biochem. J., 382: 793-801, 2004.

29) Differential Ca2+ responses induced by thrombin and thrombin-receptor agonist peptides in HSY-EA1 cells.

Tanimura A., Shitara A., Nezu A., Morita T. and Tojyo Y.

Cell Biol. Int., 27: 1017-1023, 2003.

28) Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1).

Tanaka N., Morita T., Nezu A., Tanimura A., Mizoguchi I. and Tojyo Y.

Life Sci., 73: 301-310, 2003.

27) Trafficking of green fluorescent protein-tragged SNARE proteins in HSY cells.

Takuma T., Arakawa T., Okayama M., Mizoguchi I., Tanimura A. and Tajima Y.

J. Biochem., 132: 729-735, 2002.

26) Interplay between calcium, diacylglycerol, and phosphorylation in the spatial and temporal regulation of PKCalpha -GFP.

Tanimura A., Nezu A., Morita T., Hashimoto N. and Tojyo Y.

J. Biol. Chem., 277(32): 29054-29062, 2002.

25) Comparison of amylase mRNAs from rat parotid gland, pancreas and liver using reverse transcriptase-polymerase chain reaction.

Nezu N., Morita T., Tanimura A.and Tojyo Y.

Arch. Oral Biol., 47: 563-566, 2002.

24) Evidence that zymogen granules do not function as an intracellular Ca2+ store for the generation of the Ca2+ signal in rat parotid acinar cells.

Nezu N., Tanimura A., Morita T., Irie K., Yajima T. and Tojyo, Y

Biochem. J., 363, 59-66: 2002.

23) Visualization of inositol 1,4,5-trisphosphate receptor type III with green fluorescent protein in living cells.

Morita T., Tanimura A., Nezu A. and Tojyo Y.

Cell Calcium, 31, 59-64, 2002.

22) 唾液腺細胞のCa2+シグナルと水・電解質分泌の調節機構

谷村　明彦

歯科基礎医学会雑誌, 43(4), 343-352, 2001.

21) Possible mechanisms regulating ATP- and thimerosal-induced Ca2+ oscillations in the HSY salivary duct cell line.

Tojyo Y., Tanimura A., Nezu A. and Morita T.

Biochim. Biophys. Acta, 1539(1-2): 114-21, 2001.

20) Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

Tanimura A., Tojyo Y. and Turner R. J.

J. Biol. Chem., 275: 27488-27493, 2000.

19) Characterization of the Ca2+ response mediated by activation of beta-adrenoceptors in rat submandibular ducts.

Nezu A., Tanimura A. and Y. Tojyo

Jpn. J. Pharmacol., 84: 25-31, 2000.

18) Percoll遠心分離法によるラット顎下腺導管細胞の単離

根津　顕弘，谷村　明彦，東城　庸介

東日本歯学雑誌,1, 15-22, 2000.

17) 5-Hydroxytryptamine induces transient Ca2+ influx through Ni2+-insensitive Ca2+ channels in rat smooth muscle cells.

Hirafuji M., Kawahara F., Ebihara T., Nezu A., Tanimura A. and Minami M.

Eur. J. Pharmacol., 380: 163-170, 1999.

16) Isoproterenol potentiates α-adrenergic and muscarinic receptor-mediated Ca2+ response in rat parotid cells.

Tanimura A., Nezu A., Tojyo Y. and Matsumoto Y.

Am. J. Physiol., 276: C1282-C1287, 1999.

15) Activation of b-adrenoceptors does not cause any change in cytosolic Ca2+ distribution in rat parotid acinar cells.

Tojyo Y., Tanimura A., Nezu A. and Matsumoto A.

Eur. J. Pharmacol., 360: 73-79, 1998.

14) Analysis of spatial and temporal characteristics of Ca2+ release in permeabilized parotid cells.

Tanimura A., Tojyo Y. and Matsumoto Y.

Eur. J. Morphol., 36: 157-160, 1998.

13) Imaging of quantal calcium release in the inositol 1,4,5-trisphosphate-sensitive organelles of permeabilized HSY cells.

Tanimura A., Tojyo Y. and Matsumoto Y.

Cell Struc. Func., 23: 129-135, 1998.

12) Polarized Ca2+ release in saponin-permeabilized parotid acinar cells evoked by flash photolysis of 'caged' inositol 1, 4, 5-trisphosphate.

Tanimura A., Matsumoto Y. and Tojyo Y.

Biochem. J., 332: 769-772, 1998.

11) Digital imaging of intracellular Ca2+ signaling in rat parotid acinar cells.

Tojyo Y., Tanimura A. and Matsumoto Y.

Life Sci., 62: 1635-1639, 1998.

10) Imaging of calcium release in inositol 1,4,5-trisphosphate-sensitive internal stores in permeabilized HSY cells using fluorescent indicators.

Tanimura A., Tojyo Y., Matsumoto Y. and Yajima T.

Cell Struc. Func., 23: 1-7, 1998.

9) 塩素感受性蛍光色素SPQによるラット耳下腺腺房細胞内Cl-濃度の測定

谷村　明彦，東城　庸介，松本　仁人

東日本歯学雑誌, 23: 1-7, 1998.

8) Inhibitory effects of extracellular ATP on the Ca2+ mobilization evoked by muscarinic stimulation in rat parotid acinar cells.

Tojyo Y., Tanimura A. and Matsumoto Y.

Higashi Nippon Dent. J., 16: 217-226, 1997.

7) Monitoring of Ca2+ release from intracellular stores in permeabilized rat parotid acinar cells using the fluorescent indicators Mag-fura-2 and Calcium Green C18.

Tojyo Y., Tanimura A. and Matsumoto Y.

Biochem. Biophys. Res. Commun., 240: 189-195, 1997.

6) Imaging of intracellular Ca2+ waves induced by muscarinic receptor stimulation in rat parotid acinar cells.

Tojyo Y., Tanimura A. and Matsumoto Y.

Cell Calcium, 22, 455-462, 1997.

5) Effects of extracellular ATP on cytosolic Ca2+ concentration and secretory responses in rat parotid acinar cells.

Tojyo Y., Tanimura A., Matsui S. and Matsumoto Y.

Arch. Oral Biol., 42: 393-399, 1997.

4) 非興奮性細胞におけるカルシウム流入機構研究の新しい展開．

東城　庸介，谷村　明彦，松本　仁人

日本薬理学雑誌, 110: 163-172, 1997.

3) 器官-その新しい視点（唾液腺）

東城　庸介，谷村　明彦

生体の科学, 47: 359-362, 1996.

2) Inositol 1,4,5-trisphoshate-dependent oscillations of luminal [Ca2+]L in permieabilized HSY cells.

Tanimura A. and Turner R.J.

J. Biol. Chem., 271: 30904-30908, 1996.

1) Calcium release in HSY cells conforms to a steady-state mechanism involving regulation of the inositol 1,4,5-trisphoshate receptor Ca2+ channel by luminal [Ca2+]i.

Tanimura A. and Turner R.J.

J. Cell Biol., 132: 607-616, 1996.