研究概要

研究実績

最近の研究業績

Healthy Patients With AKR1D1 Mutation Not Requiring Primary Bile Acid Therapy: A Case Series Akihiko Kimura 1 2, Jun Mori, Anh-Hoa Nguyen Pham, Kim-Oanh Bui Thi, Hajime Takei, Tsuyoshi Murai, Hisamitsu Hayashi, Hiroshi Nittono. JPGN Rep. 4(4), e372 (2023).
Profiling of Urinary Glucuronidated Bile Acids across Age Groups.Muto Y, Suzuki M, Kakiyama G, Sasaki T, Murai T, Takei H, Nittono H. Metabolites. 12, 1230 (2022) IF:4.1
Characterization of long-chain fatty acid-linked bile acids: a major conjugation form of 3β-hydroxy bile acids in feces. Takei H, Narushima S, Suzuki M, Kakiyama G, Sasaki T, Murai T, Yamashiro Y, Nittono H. J Lipid Res. 2022 Oct;63(10): IF:6.7
Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes. Lee JW, Cowley ES, Wolf PG, Doden HL, Murai T, Caicedo KYO, Ly LK, Sun F, Takei H, Nittono H, Daniel SL, Cann I, Gaskins HR, Anantharaman K, Alves JMP, Ridlon JM.
Gut Microbes. 2022 Jan-Dec;14(1): IF:12.2
A Japanese prospective multicenter study of urinary oxysterols in biliary atresia. Konishi KI, Mizuochi T, Takei H, Yasuda R, Sakaguchi H, Ishihara J, Takaki Y, Kinoshita M, Hashizume N, Fukahori S, Shoji H, Miyano G, Yoshimaru K, Matsuura T, Sanada Y, Tainaka T, Uchida H, Kubo Y, Tanaka H, Sasaki H, Murai T, Fujishiro J, Yamashita Y, Nio M, Nittono H, Kimura A. Sci Rep. 2;11(1):4986. (2021). IF:4.379
Bile Acid Synthesis Disorders in Japan: Long-Term Outcome and Chenodeoxycholic Acid Treatment.
Kimura A, Mizuochi T, Takei H, Ohtake A, Mori J, Shinoda K, Hashimoto T, Kasahara M, Togawa T, Murai T, Iida T, Nittono H. Dig Dis Sci. 66(11):3885-3892. (2021). IF:3.487
Berberine alters gut microbial function through modulation of bile acids.
Wolf PG, Devendran S, Doden HL, Ly LK, Moore T, Takei H, Nittono H, Murai T, Kurosawa T, Chlipala GE, Green SJ, Kakiyama G, Kashyap P, McCracken VJ, Gaskins HR, Gillevet PM, Ridlon JM. BMC Microbiol. 11, 21(1)-24. (2021) IF:4.465
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. Sato Y, Atarashi K, Plichta DR, Arai Y, Sasajima S, Kearney SM, Suda W, Takeshita K, Sasaki T, Okamoto S, Skelly AN, Okamura Y, Vlamakis H, Li Y, Tanoue T, Takei H, Nittono H, Narushima S, Irie J, Itoh H, Moriya K, Sugiura Y, Suematsu M, Moritoki N, Shibata S, Littman DR, Fischbach MA, Uwamino Y, Inoue T, Honda A, Hattori M, Murai T, Xavier RJ, Hirose N, Honda K. Nature. 599(7885), 458-464 (2021).　IF:69.504
Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition. J Lipid Res., Kakiyama G, Marques D, Martin R, Takei H, Rodriguez-Agudo D, LaSalle SA, Hashiguchi T, Liu X, Green R, Erickson S, Gil G, Fuchs M, Suzuki M, Murai T, Nittono H, Hylemon PB, Zhou H, Pandak WM. 61(12) 1629-1644 (2020). IF:5.922.
Analysis of steryl glucosides in rice bran-based fermented food by LC/ESI-MS/MS. Murai T, Jin S, Itoh M, Horie Y, Higashi T, Ikegawa S. Steroids, 158, 108605 (2020). IF:2.668
Changes in conjugated urinary bile acids across age groups. Sato K, Kakiyama G, Suzuki M, Naritaka N, Takei H, Sato H, Kimura A, Murai T, Kurosawa T, Pandak WM, Nittono H, Shimizu T. Steroids, 164, 108730 (2020). IF:2.668
Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes. Kimura A, Kagawa T, Takei H, Maruo Y, Sakugawa H, Sasaki T, Murai T, Naritaka N, Takikawa H, Nittono H. Hepatol Commun., 5(4), 629-633 (2020). IF:5.703
The ‘in vivo lifestyle’ of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice. Ridlon JM, Devendran S, Alves JM, Doden H, Wolf PG, Pereira GV, Ly L, Volland A, Takei H, Nittono H, Murai T, Kurosawa T, Chlipala GE, Green SJ, Hernandez AG, Fields CJ, Wright CL, Kakiyama G, Cann I, Kashyap P, McCracken V, Gaskins HR. Gut Microbes., (3), 381-404 (2020). IF: 10.245
Use of dried urine spots for screening of inborn errors of bile acid synthesis. N.Naritaka , M.Suzuki, H.Takei , H-L.Chen , S-H.Oh , P.Kaewplang , C.Zhang , T.Murai , T.Kurosawa , A.Kimura, T.Shimizu , H.Nittono. Pediatr Int. 2019 May;61(5):489-494. IF：1.139

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