口腔構造・機能発育学系 組織学

研究実績

2024年

・Seki Yuri, Takebe Hiroaki, Nakao Yuya, Sato Kohei, Mizoguchi Toshihide, Hosoya Akihiro. Osteoblast differentiation of Gli1⁺ cells via Wnt and BMP signaling pathways during orthodontic tooth movement. J Oral Biosci 66(2):373-380, 2024.

・仲川碩,門貴司,根津尚史,建部廣明,永野恵司,古市保志.細菌汚染された粗面のチタン表面に対する除去法と生物学的成長因子を用いた骨分化の検討..北医療大歯誌. 43(1):1-14, 2024.

・Hosoya Akihiro, Takebe Hiroaki, Hosoya A, Seki-Kishimoto Yuri, Noguchi Yukiko, Ninomiya Tadashi, Yukita Akira, Yoshiba Nagako, Washio Ayako, Iijima Masahiro, Morotomi Takahiko, Kitamura Chiaki, Nakamura Hiroaki. Polycomb protein Bmi1 promotes odontoblast differentiation by accelerating Wnt and BMP signaling pathways. Histochem Cell Biol 163(1):11, 2024.

・Takebe Hiroaki, Sato Hanaka, Mizoguchi Toshihide, Hosoya Akihiro. Localization of α-smooth muscle actin in osteoblast differentiation during periodontal development. Cell Tissue Res 399(1):119-127, 2024.

・Seki Yuri, Takebe Hiroaki, Nakao Yuya, Sato Kohei, Mizoguchi Toshihide, Nakamura Hiroaki, Iijima Masahiro, Hosoya Akihiro. Osteoblast differentiation of Gli1+ cells via Wnt and BMP signaling pathways during orthodontic tooth movement. J. Oral Sci, 66(2):373-380, 2024.

 

2023年

・ Fujii Saki, Takebe Hiroaki, Mizoguchi Toshihide, Nakamura Hiroaki, Shimo Tsuyoshi, Hosoya Akihiro. Bone formation ability of Gli1+ cells in the periodontal ligament after tooth extraction. Bone 173:116786, 2023.

・Shamsoon Karnoon, Hiraki Daichi, Yoshida Koki, Takabatake Kiyofumi, Takebe Hiroaki, Yokozeki Kenji, Horie Naohiro, Fujita Naomasa, Nisrina Ekayani Nasrun, Okui Tatsuo, Nagatsuka Hitoshi, Abiko Yoshihiro, Hosoya Akihiro, Saito Takashi, Shimo Tsuyoshi. The Role of Hedgehog Signaling in the Melanoma Tumor Bone Microenvironment. Int J Mol Sci 24(10):8862, 2023.

・Shibui Toru, Hosoya Akihiro, Takebe Hiroaki, Takahashi Masami, Seki Yuri, Fujii Saki, Irie Kazuharu. Immunohistochemical localization of CD146 and alpha-smooth muscle actin during dentin formation and regeneration. Anat Rec, 306(8):2199-2207, 2023.

・Shimo Tsuyoshi, Takebe Hiroaki, Fujii Saki, Hosoya Akihiro. Immunohistochemical analysis of CCN2 in experimental fracture healing models. Methods Mol Biol 2582:335-342, 2023.

 

2022年

・ Seki Yuri, Takebe Hiroaki, Mizoguchi Toshihide, Nakamura Hiroaki, Iijima Masahiro, Irie Kazuharu, Hosoya Akihiro. Differentiation ability of Gli1+ cells during orthodontic tooth movement. Bone 166:116609, 2022.

・Shalehin Nazmus, Seki Yuri, Takebe Hiroaki, Fujii Saki, Mizoguchi Toshihide, Nakamura Hiroaki, Yoshiba Nagako, Yoshiba Kunihiko, Iijima Masahiro, Shimo Tsuyoshi, Irie Kazuharu, Hosoya Akihiro. Gli1+-PDL cells contribute to alveolar bone homeostasis and regeneration. J Dent Res, 101(12):1537-1543, 2022.

・Murata Masaru, Nezu Takashi, Takebe Hiroaki, Hirose Yukito, Okubo Naoto, Saito Takashi, Akazawa Toshiyuki. Human dentin materials for minimally invasive bone regeneration: Animal studies and clinical cases. J. Oral Sci, 65(1):13-18, 2022.

 

2021年

・Hiroaki Takebe, Kazuharu Irie, Akihiro Hosoya. Localization of Bmi1 in osteoblast-lineage cells during endochondral ossification.  The Anatomical Record, 1-7, 2021.

・Daisuke Nishida, Atsushi Arai, Lijuan Zhao, Mengyu Yang, Yuko Nakamichi, Kanji Horibe, Akihiro Hosoya, Yasuhiro Kobayashi, Nobuyuki Udagawa, Toshihide Mizoguchi. RANKL/OPG ratio regulates odontoclastogenesis in damaged dental pulp.  Scientific Reports, 11:4575, 2021.

・Lijuan Zhao, Shinichirou Ito, Atsushi Arai, Nobuyuki Udagawa, Kanji Horibe, Miroku Hara, Daisuke Nishida, Akihiro Hosoya, Rinya Masuko, Koji Okabe, Masashi Shin, Xianqi Li, Koichi Matsuo, Shinichi Abe, Satoru Matsunaga, Yasuhiro Kobayashi, Hideaki Kagami, Toshihide Mizoguchi. Odontoblast death drives cell-rich zone-derived dental tissue regeneration.  Bone, 150:116010, 2021.

 

2020年

・Akihiro Hosoya, Shalehin Nazmus, Hiroaki Takebe, Saki Fujii, Yuri Seki, Toshihide Mizoguchi, Tsuyoshi Shimo, Masahiro Iijima, Kazuharu Irie. Stem cell properties of Gli1-positive cells in the periodontal ligament. J Oral Biosci, 62:299-305, 2020.

・Shalehin Nazmus, Akihiro Hosoya, Hiroaki Takebe, Md Riasat Hasan, Kazuharu Irie. Boric acid inhibits alveolar bone loss in rat experimental periodontitis through diminished bone resorption and enhanced osteoblast formation. J Dent Sci, 15:437-444, 2020.

・建部廣明,秋月一城,藤田景子,Nazmus Shalehin,川村尚彦,細矢明宏,中山英二,入江一元. マイクロCTを用いた歯内歯の三次元形態解析. 北医療大歯誌. 39(1):11-15, 2020.

・尾立卓弥,中尾友也,細矢明宏,飯島雅弘. 顎関節への荷重負荷がラット下顎頭軟骨の基質タンパク発現に与える影響. 北医療大歯誌. 39(1):1-10, 2020.

・Tsuyoshi Shimo, Hiroaki Takebe, Tatsuo Okui, Yuki Kunisada, Soichiro Ibaragi, Kyoichi Obata, Naito Kurio, Karnoon Shamsoon, Saki Fujii, Akihiro Hosoya, Kazuharu Irie, Akira Sasaki, Masahiro Iwamoto. Expression and role of IL-1β signaling in chondrocytes associated with retinoid signaling during fracture healing. Int J Mol Sci. 21(7):2365, 2020.

・Akihiro Hosoya, Shalehin Nazmus, Hiroaki Takebe, Tsuyoshi Shimo, Kazuharu Irie. Sonic hedgehog signaling and tooth development. Int J Mol Sci. 21(5):1587, 2020.

・Nagako Yoshiba, Naoki Edanami, Naoto Ohkura, Tomoki Maekawa, Naoki Takahashi, Aiko Tohma, Kenji Izumi, Takeyasu Maeda, Akihiro Hosoya, Hiroaki Nakamura, Koichi Tabeta, Yuichiro Noiri, Kunihiko Yoshiba (2020) M2 phenotype macrophages colocalize with Sshwann cells in human dental pulp. J Dent Res 99(3):329-338, 2020.

・Hiroaki Takebe, Shalehin Nazmus, Akihiro Hosoya, Tsuyoshi Shimo, Kazuharu Irie. Sonic hedgehog regulates bone fracture healing. Int J Mol Sci. 21 (2):677, 2020.

研究概要